Table of Contents
ISRN Organic Chemistry
Volume 2014 (2014), Article ID 120173, 9 pages
Research Article

Synthesis, Spectral Analysis, In Vitro Microbiological Evaluation, and Molecular Docking Studies of Some Novel 1-(1-Aryl-1H-tetrazol-5-yl)-2-(piperidin-1-yl)ethanone Derivatives

Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University, Annamalai Nagar, Tamil Nadu 608 002, India

Received 20 February 2014; Accepted 6 April 2014; Published 6 May 2014

Academic Editors: H. G. Bonacorso, F. Felluga, and N. Zanatta

Copyright © 2014 Thangasamy Elavarasan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A new series of novel heterocyclic compounds containing both tetrazoles and piperidine nuclei together, namely, 1-(1-aryl-1H-tetrazol-5-yl)-2-(piperidin-1-yl)ethanone (2228), were synthesized by the treatment of the respective 2-chloro-1-(1-aryl-1H-tetrazol-5-yl)ethanone (1521) with piperidine in acetonitrile for 6 h. A series of novel tetrazole substituted piperidine derivatives were synthesized and evaluated for their antimicrobial activity using serial dilution method. The structures of the synthesized compounds were characterized by IR, 1H NMR, 13C NMR, mass spectral data, and elemental analysis. Evaluation of antimicrobial activity shows that several compounds exhibit good activity when compared with the reference drug candidates and thus could be promising new lead molecules.