Table of Contents
International Scholarly Research Notices
Volume 2014, Article ID 123257, 11 pages
http://dx.doi.org/10.1155/2014/123257
Review Article

Natural Remedies for the Treatment of Beta-Thalassemia and Sickle Cell Anemia—Current Status and Perspectives in Fetal Hemoglobin Reactivation

1School of Life Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
2Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
3CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, Hong Kong

Received 18 April 2014; Revised 21 July 2014; Accepted 25 July 2014; Published 2 October 2014

Academic Editor: David Murphy

Copyright © 2014 Noel Yat Hey Ng and Chun Hay Ko. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

For the treatment of β-thalassemia and sickle cell disease (SCD), pharmacological induction of fetal hemoglobin (HbF) production may be a promising approach. To date, numerous studies have been done on identifying the novel HbF-inducing agents and understanding the underlying mechanism for stimulating the HbF production. In this review, we have summarized the identified HbF-inducing agents by far. By examining the action mechanisms of the HbF-inducing agents, various studies have suggested that despite the ability of stimulating HbF production, the chemotherapeutic agents could not be practically applied for treating β-hemoglobinopathies, especially β-thalassemia, due to the their cytotoxicity and growth-inhibitory effect. Owing to this therapeutic obstacle, much effort has been put on identifying new HbF-inducing agents from the natural world with the combination of efficacy, safety, and ease of use. Therefore, this review aims to (i) reveal the novel screening platforms for identifying potential inducers with high efficiency and accuracy and to (ii) summarize the new identified natural remedies for stimulating HbF production. Hopefully, this review can provide a new insight into the current status and future perspectives in fetal hemoglobin reactivation for treating β-thalassaemia and SCD.