Table of Contents
ISRN Endocrinology
Volume 2014, Article ID 124974, 4 pages
Research Article

Antihyperglycaemic Effect of Tetracarpidium Conophorum Nuts in Alloxan Induced Diabetic Female Albino Rats

Chemical Pathology Unit, Department of Medical Laboratory Science, Faculty of Science, Rivers State University of Science and Technology, Nkpolu Oroworukwo, Port Harcourt, Rivers State, Nigeria

Received 14 February 2014; Accepted 30 March 2014; Published 6 May 2014

Academic Editors: Z. Canturk, B. Kim, and Y. B. Lombardo

Copyright © 2014 Donatus Onukwufor Onwuli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The antihyperglycaemic activity of Tetracarpidium conophorum nut (walnut) was investigated in albino rats. A total of 20 albino rats were used for the study. The rats were divided into five groups (A–E) of four rats each. Diabetes were induced in the rats except four which served as the positive control group A. Groups B (negative control), C, D, and E contain diabetic rats each with blood sugar level ≥17.00 mmol/L. Groups A and B were fed on 85.2 g of top feed grower over the test period. Test groups C, D, and E were fed on 21.3 g, 42.6 g, and 85.2 g of walnuts, respectively, and their fasting blood sugar (FBS) levels were checked on daily basis. Fasting blood glucose levels of the test groups were significantly lower than negative control , for 3rd, 7th, and 10th days of the test. There were also significant increase in the body weight and hemoglobin concentration and a decreased urine output of the test group compared with the controls. These results indicate that Tetracarpidium conophorum nut (walnut) has an antihyperglycemic effect in diabetic rats.