Research Article
Influence of Tableting on Enzymatic Activity of Papain along with Determination of Its Percolation Threshold with Microcrystalline Cellulose
Table 3
Stability of papain powder tablet alone and in combination with different excipients under accelerated storage conditions (40 ± 2°C/75 ± 5% RH).
| | Formulation | % activity remaining | (days−1) | | 0 M | 1.5 M | 3 M | 6 M |
| | PP | 100.00 ± 3.12 | 94.07 ± 2.75 | 83.56 ± 3.18 | 75.84 ± 2.87 | 1.54 × 10−3 | | PM | 100.00 ± 2.61 | 97.54 ± 2.13 | 94.53 ± 1.66 | 88.69 ± 2.19 | 6.67 × 10−4 | | PD | 100.00 ± 3.48 | 96.21 ± 2.67 | 93.50 ± 3.61 | 87.14 ± 4.62 | 7.65 × 10−4 | | PC | 100.00 ± 2.24 | 96.18 ± 4.51 | 92.45 ± 3.81 | 83.62 ± 3.26 | 9.94 × 10−4 | | PA | 100.00 ± 3.28 | 94.41 ± 1.94 | 90.32 ± 4.45 | 82.96 ± 5.14 | 1.04 × 10−3 | | PT | 100.00 ± 3.09 | 95.04 ± 1.93 | 91.74 ± 4.19 | 83.06 ± 4.11 | 1.03 × 10−3 |
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Values are mean ± SE (); M: months; : calculated first-order degradation rate constant.
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