Influence of Tableting on Enzymatic Activity of Papain along with Determination of Its Percolation Threshold with Microcrystalline Cellulose

Table 4

Stability of papain tablet alone and along with different excipients under room temperature storage (30 ± 2°C/65 ± 5% RH).

Formulation	% activity remaining					(days^−1)	(days)
	0 M	3 M	6 M	9 M	12 M
PP	100.00 ± 3.16	95.56 ± 4.61	88.97 ± 3.48	81.48 ± 4.62	74.87 ± 4.64	7.93 × 10^−4	131.14
PM	100.00 ± 2.61	96.71 ± 2.61	94.08 ± 2.04	91.80 ± 2.22	89.07 ± 2.44	3.17 × 10^−4	327.89
PD	100.00 ± 3.13	97.16 ± 2.61	94.78 ± 2.49	92.08 ± 3.82	88.27 ± 3.27	3.42 × 10^−4	304.18
PC	100.00 ± 3.06	96.12 ± 3.19	92.04 ± 3.78	89.80 ± 2.93	84.47 ± 1.77	4.62 × 10^−4	224.88
PA	100.00 ± 2.13	97.01 ± 2.18	94.08 ± 4.04	88.80 ± 4.20	84.01 ± 3.56	4.77 × 10^−4	217.83
PT	100.00 ± 4.01	96.01 ± 2.69	91.81 ± 2.74	87.23 ± 3.43	83.76 ± 1.77	4.86 × 10^−4	214.16

Values are mean ± SE (); M: months; : calculated first-order degradation rate constant; : time to reach 90% of initial drug concentration.