Malignancy Associated MicroRNA Expression Changes in Canine Mammary Cancer of Different Malignancies

Table 1

miRNA and snoRNA expression differences between mammary tissues at different stages of malignancy and normal gland.

	Normal	Adenoma	Nonmetastasizing carcinoma	Metastasizing carcinoma	Metastasis	Regulation
Normal		miR-203 (4.37); miR-210 (7.01)	miR-143 (2.70); miR-21 (3.18); miR-210 (10.41); miR-194 (4.44)	miR-21 (5.05); miR-210 (10.72)	miR-210 (19.63)	Up
				U24 (0.38)	miR-143 (0.04),; miR-145 (0.02),; miR-101 (0.12)	Down
Adenoma						Up
				miR-125a (0.40)	miR-143 (0.02),; miR-145 (0.02),; miR-101 (0.05),; miR-29b (0.14)	Down
Nonmetastasizing carcinoma						Up
					miR-143 (0.02),; miR-145 (0.01),; miR-101 (0.08),; miR-29b (0.18)	Down
Metastasizing carcinoma					miR-125a (4.91)	Up
					miR-143 (0.06),; miR-145 (0.04),; miR-101 (0.13),; miR-29b (0.18)	Down
Metastasis						Up
						Down

In brackets (): fold change in expression difference.