Table of Contents
ISRN Neuroscience
Volume 2014, Article ID 163459, 8 pages
http://dx.doi.org/10.1155/2014/163459
Research Article

Prenatal Exposure to Lamotrigine: Effects on Postnatal Development and Behaviour in Rat Offspring

1Centre for Toxicology and Developmental Research (CEFT), Sri Ramachandra University, Chennai, Tamil Nadu 600116, India
2Department of Biochemistry, Sri Ramachandra University, Chennai, Tamil Nadu 600116, India
3School of Chemical and Biotechnology, Shanmugha Arts, Science, Technology and Research Academy (SASTRA University), Thanjavur, Tamil Nadu 613402, India

Received 11 January 2014; Accepted 19 February 2014; Published 14 April 2014

Academic Editors: I. Berger, A. M. Depino, and R. Kulesza

Copyright © 2014 Sekar Sathiya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. B. Holmes, “The teratogenicity of anticonvulsant drugs: a progress report,” Journal of Medical Genetics, vol. 39, no. 4, pp. 245–247, 2002. View at Google Scholar · View at Scopus
  2. K. J. Meador, G. A. Baker, R. H. Finnell et al., “In utero antiepileptic drug exposure: fetal death and malformations,” Neurology, vol. 67, no. 3, pp. 407–412, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. E. Perucca, “Birth defects after prenatal exposure to antiepileptic drugs,” The Lancet Neurology, vol. 4, no. 11, pp. 781–786, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. N. Adab, A. Jacoby, D. Smith, and D. Chadwick, “Additional educational needs in children born to mothers with epilepsy,” Journal of Neurology Neurosurgery and Psychiatry, vol. 70, no. 1, pp. 15–21, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Vinten, N. Adab, U. Kini, J. Gorry, J. Gregg, and G. A. Baker, “Neuropsychological effects of exposure to anticonvulsant medication in utero,” Neurology, vol. 64, no. 6, pp. 949–954, 2005. View at Google Scholar · View at Scopus
  6. J.-B. Manent, I. Jorquera, I. Mazzucchelli et al., “Fetal exposure to GABA-acting antiepileptic drugs generates hippocampal and cortical dysplasias,” Epilepsia, vol. 48, no. 4, pp. 684–693, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. D. Janz and U. Fuchs, “Are anti epileptic drugs harmful during pregnancy?” Deutsche Medizinische Wochenschrift, vol. 89, pp. 241–248, 1964. View at Google Scholar
  8. B. R. Danielsson, K. Lansdell, L. Patmore, and T. Tomson, “Effects of the antiepileptic drugs lamotrigine, topiramate and gabapentin on hERG potassium currents,” Epilepsy Research, vol. 63, no. 1, pp. 17–25, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. V. Des Portes, I. Souville, F. Francis et al., “So-called “cryptogenic” partial seizures resulting from a subtle cortical dysgenesis due to a doublecortin gene mutation,” Seizure, vol. 11, no. 4, pp. 273–277, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. K. J. Meador, G. A. Baker, N. Browning et al., “Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs,” The New England Journal of Medicine, vol. 360, no. 16, pp. 1597–1605, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. G. Veiby, A. K. Daltveit, S. Schjolberg et al., “Exposure to antiepileptic drugs in utero and child development: a prospective population-based study,” Epilepsia, vol. 54, no. 8, pp. 1462–1472, 2013. View at Google Scholar
  12. C. T. Clark, A. M. Klein, J. M. Perel et al., “Lamotrigine dosing for pregnant patients with bipolar disorder,” The American Journal of Psychiatry, vol. 170, no. 11, pp. 240–247, 2013. View at Google Scholar
  13. J.-B. Manent, I. Jorquera, V. Franco, Y. Ben-Ari, E. Perucca, and A. Represa, “Antiepileptic drugs and brain maturation: fetal exposure to lamotrigine generates cortical malformations in rats,” Epilepsy Research, vol. 78, no. 2-3, pp. 131–139, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. I. Katz, J. Kim, K. Gale, and A. Kondratyev, “Effects of lamotrigine alone and in combination with MK-801, phenobarbital, or phenytoin on cell death in the neonatal rat brain,” Journal of Pharmacology and Experimental Therapeutics, vol. 322, no. 2, pp. 494–500, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Pellow and S. E. File, “Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat,” Pharmacology Biochemistry and Behavior, vol. 24, no. 3, pp. 525–529, 1986. View at Google Scholar · View at Scopus
  16. E. Appenrodt, R. Schnabel, and H. Schwarzberg, “Vasopressin administration modulates anxiety-related behavior in rats,” Physiology and Behavior, vol. 64, no. 4, pp. 543–547, 1998. View at Publisher · View at Google Scholar · View at Scopus
  17. S. E. Bowen, J. L. Wiley, and R. L. Balster, “The effects of abused inhalants on mouse behavior in an elevated plus-maze,” European Journal of Pharmacology, vol. 312, no. 2, pp. 131–136, 1996. View at Publisher · View at Google Scholar · View at Scopus
  18. E. F. Espejo, “Effects of weekly or daily exposure to the elevated plus-maze in male mice,” Behavioural Brain Research, vol. 87, no. 2, pp. 233–238, 1997. View at Publisher · View at Google Scholar · View at Scopus
  19. T. Skutella, J. C. Probst, U. Renner, F. Holsboer, and C. Behl, “Corticotropin-releasing hormone receptor (type I) antisense targeting reduces anxiety,” Neuroscience, vol. 85, no. 3, pp. 795–805, 1998. View at Publisher · View at Google Scholar · View at Scopus
  20. R. G. Lister, “Ethologically-based animal models of anxiety disorders,” Pharmacology and Therapeutics, vol. 46, no. 3, pp. 321–340, 1990. View at Google Scholar · View at Scopus
  21. D. S. Olton, C. Collison, and M. A. Werz, “Spatial memory and radial arm maze performance of rats,” Learning and Motivation, vol. 8, no. 3, pp. 289–314, 1977. View at Google Scholar · View at Scopus
  22. T. Tamayama, K. Maemura, K. Kanbara et al., “Expression of GABAA and GABAB receptors in rat growth plate chondrocytes: activation of the GABA receptors promotes proliferation of mouse chondrogenic ATDC5 cells,” Molecular and Cellular Biochemistry, vol. 273, no. 1-2, pp. 117–126, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. P. Prakash, L. V. Prabhu, M. A. Nasar, R. Rai, S. Madhyastha, and G. Singh, “Lamotrigine in pregnancy: safety profile and the risk of malformations,” Singapore Medical Journal, vol. 48, no. 10, pp. 880–883, 2007. View at Google Scholar · View at Scopus
  24. P. A. Forcelli, M. J. Janssen, L. A. Stamps, C. Sweeney, S. Vicini, and K. Gale, “Therapeutic strategies to avoid long-term adverse outcomes of neonatal antiepileptic drug exposure,” Epilepsia, vol. 51, no. 3, pp. 18–23, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. GenRx, The Complete Reference for Generic and Brand Drugs, Mosby, St Louis, Mo, USA, 9th edition, 1999.
  26. T. Tomson, E. Perucca, and D. Battino, “Navigating toward fetal and maternal health: the challenge of treating epilepsy in pregnancy,” Epilepsia, vol. 45, no. 10, pp. 1171–1175, 2004. View at Publisher · View at Google Scholar · View at Scopus
  27. J. Sidhu, S. Job, S. Singh, and R. Philipson, “The pharmacokinetic and pharmacodynamic consequences of the co-administration of lamotrigine and a combined oral contraceptive in healthy female subjects,” British Journal of Clinical Pharmacology, vol. 61, no. 2, pp. 191–199, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. H. A. Valsamis, S. K. Arora, B. Labban, and S. I. McFarlane, “Antiepileptic drugs and bone metabolism,” Nutrition and Metabolism, vol. 3, article 36, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. A. Reimers, G. Helde, and E. Brodtkorb, “Ethinyl estradiol, not progestogens, reduces lamotrigine serum concentrations,” Epilepsia, vol. 46, no. 9, pp. 1414–1417, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. C. H. Bueno, H. Zangrossi Jr., and M. B. Viana, “The inactivation of the basolateral nucleus of the rat amygdala has an anxiolytic effect in the elevated T-maze and light/dark transition tests,” Brazilian Journal of Medical and Biological Research, vol. 38, no. 11, pp. 1697–1701, 2005. View at Google Scholar · View at Scopus
  31. S. K. Sanders, S. L. Morzorati, and A. Shekhar, “Priming of experimental anxiety by repeated subthreshold GABA blockade in the rat amygdala,” Brain Research, vol. 699, no. 2, pp. 250–259, 1995. View at Publisher · View at Google Scholar · View at Scopus
  32. K. M. Olesen, N. Ismail, E. D. Merchasin, and J. D. Blaustein, “Long-term alteration of anxiolytic effects of ovarian hormones in female mice by a peripubertal immune challenge,” Hormones and Behavior, vol. 60, no. 4, pp. 318–326, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. M. J. Morrell, “Epilepsy in women,” American Family Physician, vol. 66, no. 8, pp. 1489–1494, 2002. View at Google Scholar · View at Scopus