Prenatal Exposure to Lamotrigine: Effects on Postnatal Development and Behaviour in Rat Offspring

Table 1

Effect of LTG on dam body weight and feed and water consumption.

Treatment	Control	LTG (mg/kg, p.o)
		11.5	23	46
Dam body weight (g)
GND 3	182.00±6.00	165.00±1.20	169.83±3.56	183.69±7.82
GND 7	187.00±8.50	171.67±1.64	168.83±4.12	180.50±4.85
GND 14	227.50±13.25	188.33±5.60^∗	185.53±5.64^∗	178.33±9.91^∗∗
GND 21	242.00±8.50	201.66±12.88^∗	191.00±9.16^∗∗	—
Cumulative feed consumption (g/dam)
GND 3–6	40.75±2.37	37.00±3.14	39.29±1.37	41.37±3.48
GND 7–14	86.00±1.14	60.28±4.26^∗∗	58.00±2.09^∗∗	47.56±0.96^∗∗
GND 15–21	88.50±1.86	65.25±2.50^∗∗	60.80±1.52^∗∗	—
Cumulative water consumption (mL)
GND 3–6	43.39±0.31	41.25±2.32	39.77±0.29	44.56±1.55
GND 7–14	102.50±0.59	96.54±1.56^∗	95.80±1.09^∗∗	91.00±1.33^∗∗
GND 15–21	95.50±1.08	86.59±2.03^∗∗	85.80±1.17^∗∗	—

𝑛=6/group. Values are expressed in mean ± SEM. Significance with Tukey’s test following one way ANOVA is indicated as ^∗𝑃≤0.05 and ^∗∗𝑃≤0.01 versus control group; GND: gestational day; LTG: lamotrigine.