Prenatal Exposure to Lamotrigine: Effects on Postnatal Development and Behaviour in Rat Offspring

Table 5

Effect of LTG on locomotor function in male and female offspring.

Group	Treatment	Sex	Number of squares crossed	Immobility period (sec)	Number of rearing	Number of grooming
I	Control	Male	89.25±7.45	100.25±21.99	27.25±2.43	8.25±1.25
		Female	109.60±7.78	72.00±11.36	37.60±4.95	7.40±0.75
II	LTG (11.5 mg/kg, p.o)	Male	87.00±5.29	74.50±13.82	28.00±1.34	6.17±0.54
		Female	109.50±6.50	81.42±17.32	46.50±3.50	9.00±3.00
III	LTG (23 mg/kg, p.o)	Male	77.52±16.40	112.03±41.11	20.85±3.85	6.12±1.07
		Female	113.58±4.64	50.00±10.00	51.75±1.00^∗	5.08±0.63

𝑛=8/group (4/sex). Values are expressed in mean ± SEM. Significance with Tukey’s test following one way ANOVA is indicated as ^∗𝑃≤0.05 versus control group.