Table of Contents
International Scholarly Research Notices
Volume 2014, Article ID 239575, 5 pages
http://dx.doi.org/10.1155/2014/239575
Clinical Study

Atorvastatin Treatment Does Not Alter Pulse Wave Velocity in Healthy Adults

1Division of Cardiology, Henry Low Heart Center, Hartford Hospital, Hartford, CT 06102, USA
2Department of Health Sciences and Nursing, University of Hartford, West Hartford, CT 06117, USA
3School of Pharmacy, University of Connecticut, Storrs, CT 06269, USA

Received 12 August 2014; Revised 24 October 2014; Accepted 25 October 2014; Published 13 November 2014

Academic Editor: Ahmed Abdel-Latif

Copyright © 2014 Kevin D. Ballard et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. Both statins and regular physical activity (PA) reduce arterial stiffness. The present post hoc analysis examined if arterial stiffness was improved with high-dose atorvastatin treatment in healthy adults and whether PA levels magnified this response. We utilized data from a double-blind, random-assignment clinical trial investigating the effects of atorvastatin 80 mg/d for 6 mo on skeletal muscle symptoms. Methods. Central and peripheral arterial pulse wave velocity (PWV) were measured and PA levels assessed at baseline and 6 mo in subjects randomized to atorvastatin , 9 men) or placebo , 16 men). Results. Baseline participant characteristics, PWV, and PA levels were not different between treatments. Central (means ± SD; to  m/sec) and peripheral PWV to  m/sec) were unchanged from baseline following atorvastatin treatment (time × drug interaction: . Similarly, PA levels were unaffected by time or treatment. In sex and age adjusted models, baseline levels of PA were not related to changes in PWV with atorvastatin treatment. Conclusion. These data indicate that high-dose atorvastatin treatment for 6 mo does not influence arterial stiffness in healthy adults. Participation in habitual PA did not magnify the vascular effects of statin therapy. This study was registered with ClinicalTrials.gov NCT00609063.