Table of Contents
International Scholarly Research Notices
Volume 2014, Article ID 239575, 5 pages
http://dx.doi.org/10.1155/2014/239575
Clinical Study

Atorvastatin Treatment Does Not Alter Pulse Wave Velocity in Healthy Adults

1Division of Cardiology, Henry Low Heart Center, Hartford Hospital, Hartford, CT 06102, USA
2Department of Health Sciences and Nursing, University of Hartford, West Hartford, CT 06117, USA
3School of Pharmacy, University of Connecticut, Storrs, CT 06269, USA

Received 12 August 2014; Revised 24 October 2014; Accepted 25 October 2014; Published 13 November 2014

Academic Editor: Ahmed Abdel-Latif

Copyright © 2014 Kevin D. Ballard et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. Dilaveris, G. Giannopoulos, M. Riga, A. Synetos, and C. Stefanadis, “Beneficial effects of statins on endothelial dysfunction and vascular stiffness,” Current Vascular Pharmacology, vol. 5, no. 3, pp. 227–237, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. V. Lahera, M. Goicoechea, S. G. de Vinuesa et al., “Endothelial dysfunction, oxidative stress and inflammation in atherosclerosis: beneficial effects of statins,” Current Medicinal Chemistry, vol. 14, no. 2, pp. 243–248, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. J. R. Downs, M. Clearfield, S. Weis et al., “Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS,” The Journal of the American Medical Association, vol. 279, no. 20, pp. 1615–1622, 1998. View at Publisher · View at Google Scholar · View at Scopus
  4. P. M. Ridker, E. Danielson, F. A. Fonseca et al., “Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein,” The New England Journal of Medicine, vol. 359, no. 21, pp. 2195–2207, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Shepherd, G. J. Blauw, M. B. Murphy et al., “Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial,” The Lancet, vol. 360, no. 9346, pp. 1623–1630, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Shepherd, S. M. Cobbe, I. Ford et al., “Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia,” The New England Journal of Medicine, vol. 333, no. 20, pp. 1301–1307, 1995. View at Publisher · View at Google Scholar · View at Scopus
  7. A. I. Kanaki, P. A. Sarafidis, P. I. Georgianos et al., “Effects of low-dose atorvastatin on arterial stiffness and central aortic pressure augmentation in patients with hypertension and hypercholesterolemia,” American Journal of Hypertension, vol. 26, no. 5, pp. 608–616, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Lunder, M. Janić, S. Habjan, and M. Šabovič, “Subtherapeutic, low-dose fluvastatin improves functional and morphological arterial wall properties in apparently healthy, middle-aged males—a pilot study,” Atherosclerosis, vol. 215, no. 2, pp. 446–451, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. K. M. Mäki-Petäjä, A. D. Booth, F. C. Hall et al., “Ezetimibe and simvastatin reduce inflammation, disease activity, and aortic stiffness and improve endothelial function in rheumatoid arthritis,” Journal of the American College of Cardiology, vol. 50, no. 9, pp. 852–858, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. J. S. Orr, A. L. Dengo, J. M. Rivero, and K. P. Davy, “Arterial destiffening with atorvastatin in overweight and obese middle-aged and older adults,” Hypertension, vol. 54, no. 4, pp. 763–768, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Pirro, G. Schillaci, M. R. Mannarino et al., “Effects of rosuvastatin on 3-nitrotyrosine and aortic stiffness in hypercholesterolemia,” Nutrition, Metabolism & Cardiovascular Diseases, vol. 17, no. 6, pp. 436–441, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. R. G. Fassett, I. K. Robertson, M. J. Ball, D. P. Geraghty, J. E. Sharman, and J. S. Coombes, “Effects of atorvastatin on arterial stiffness in chronic kidney disease: a randomised controlled trial,” Journal of Atherosclerosis and Thrombosis, vol. 17, no. 3, pp. 235–241, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Raison, A. Rudnichi, and M. E. Safar, “Effects of atorvastatin on aortic pulse wave velocity in patients with hypertension and hypercholesterolaemia: a preliminary study,” Journal of Human Hypertension, vol. 16, no. 10, pp. 705–710, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. H. Shige, A. Dart, and P. Nestel, “Simvastatin improves arterial compliance in the lower limb but not in the aorta,” Atherosclerosis, vol. 155, no. 1, pp. 245–250, 2001. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Gando, K. Yamamoto, H. Murakami et al., “Longer time spent in light physical activity is associated with reduced arterial stiffness in older adults,” Hypertension, vol. 56, no. 3, pp. 540–546, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. H. Tanaka, F. A. Dinenno, K. D. Monahan, C. M. Clevenger, C. A. DeSouza, and D. R. Seals, “Aging, habitual exercise, and dynamic arterial compliance,” Circulation, vol. 102, no. 11, pp. 1270–1275, 2000. View at Publisher · View at Google Scholar · View at Scopus
  17. P. V. Vaitkevicius, J. L. Fleg, J. H. Engel et al., “Effects of age and aerobic capacity on arterial stiffness in healthy adults,” Circulation, vol. 88, no. 4, pp. 1456–1462, 1993. View at Publisher · View at Google Scholar · View at Scopus
  18. B. A. Parker, J. A. Capizzi, A. S. Grimaldi et al., “Effect of statins on skeletal muscle function,” Circulation, vol. 127, no. 1, pp. 96–103, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. P. D. Thompson, B. A. Parker, P. M. Clarkson et al., “A randomized clinical trial to assess the effect of statins on skeletal muscle function and performance: rationale and study design,” Preventive Cardiology, vol. 13, no. 3, pp. 104–111, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. R. S. Paffenbarger Jr., A. L. Wing, and R. T. Hyde, “Physical activity as an index of heart attack risk in college alumni,” American Journal of Epidemiology, vol. 108, no. 3, pp. 161–175, 1978. View at Google Scholar · View at Scopus
  21. C. Vlachopoulos, K. Aznaouridis, and C. Stefanadis, “Prediction of cardiovascular events and all-cause mortality with arterial stiffness. A systematic review and meta-analysis,” Journal of the American College of Cardiology, vol. 55, no. 13, pp. 1318–1327, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. E. C. Rizos, A. P. Agouridis, and M. S. Elisaf, “The effect of statin therapy on arterial stiffness by measuring pulse wave velocity: a systematic review,” Current Vascular Pharmacology, vol. 8, no. 5, pp. 638–644, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. L. Gao, W. Wang, Y.-L. Li et al., “Simvastatin therapy normalizes sympathetic neural control in experimental heart failure: roles of angiotensin II type 1 receptors and NAD(P)H oxidase,” Circulation, vol. 112, no. 12, pp. 1763–1770, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. L. Gao, W. Wang, and I. H. Zucker, “Simvastatin inhibits central sympathetic outflow in heart failure by a nitric-oxide synthase mechanism,” The Journal of Pharmacology and Experimental Therapeutics, vol. 326, no. 1, pp. 278–285, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Ichihara, M. Hayashi, Y. Koura, Y. Tada, Y. Kaneshiro, and T. Saruta, “Long-term effects of statins on arterial pressure and stiffness of hypertensives,” Journal of Human Hypertension, vol. 19, no. 2, pp. 103–109, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. J. Zhou, M. Cheng, Y.-H. Liao et al., “Rosuvastatin enhances angiogenesis via eNOS -dependent mobilization of endothelial progenitor cells,” PLoS ONE, vol. 8, no. 5, Article ID e63126, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. National Center for Health Statistics, Health, United States, 2012: With Special Feature on Emergency Care, 2013, Centers for Disease Control and Prevention, 2013.