Table of Contents
ISRN Pharmacology
Volume 2014, Article ID 243575, 9 pages
http://dx.doi.org/10.1155/2014/243575
Research Article

Antihyperlipidemic Activity of Aloe succotrina in Rats: Possibly Mediated by Inhibition of HMG-CoA Reductase

1Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, Haryana 125001, India
2Padmnabham Ayurveda Hospital and Research Center, 75 Jawahar Nagar Colony, Tonk Road, Jaipur, Rajasthan, India
3M.S.M. Institute of Ayurveda, B.P.S. Mahila Vishwavidyalaya, Khanpur Kalan, Sonipat, Haryana, India

Received 2 October 2013; Accepted 7 November 2013; Published 17 February 2014

Academic Editors: G. Edwards, R. Fantozzi, T. W. Stone, and S.-N. Wu

Copyright © 2014 Dinesh Dhingra et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. D. Kolovou, K. K. Anagnostopoulou, and D. V. Cokkinos, “Pathophysiology of dyslipidaemia in the metabolic syndrome,” Postgraduate Medical Journal, vol. 81, no. 956, pp. 358–366, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. R. M. Krauss and Y. A. Kesaniemi, “Cardiovascular disease and hyperlipidaemia,” Current Opinion in Lipidology, vol. 5, no. 4, pp. 249–251, 1994. View at Publisher · View at Google Scholar · View at Scopus
  3. N. J. Stone, “Lipid management: current diet and drug treatment options,” The American Journal of Medicine, vol. 101, no. 4, supplement 1, pp. 40S–49S, 1996. View at Publisher · View at Google Scholar · View at Scopus
  4. Y. Lin, S. S. Mousa, N. Elshourbagy, and S. A. Mousa, “Current status and future directions in lipid management: emphasizing low-density lipoproteins, high-density lipoproteins, and triglycerides as targets for therapy,” Vascular Health and Risk Management, vol. 6, no. 1, pp. 73–85, 2010. View at Google Scholar · View at Scopus
  5. M. Kobayashi, T. Kagawa, K. Narumi, S. Itagaki, T. Hirano, and K. Iseki, “Bicarbonate supplementation as a preventive way in statins-induced muscle damage,” Journal of Pharmacy and Pharmaceutical Sciences, vol. 11, no. 1, pp. 1–8, 2008. View at Google Scholar · View at Scopus
  6. J. R. Guyton and H. E. Bays, “Safety considerations with niacin therapy,” The American Journal of Cardiology, vol. 99, no. 6, pp. S22–S31, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. W. C. Lakey, N. Greyshock, and J. R. Guyton, “Adverse reactions of Achilles tendon xanthomas in three hypercholesterolemic patients after treatment intensification with niacin and bile acid sequestrants,” Journal of Clinical Lipidology, vol. 7, no. 2, pp. 178–181, 2013. View at Publisher · View at Google Scholar
  8. M. Kiskac, M. Zorlu, M. Cakirca et al., “A case of rhabdomyolysis complicated with acute renal failure after resumption of fenofibrate therapy: a first report,” Indian Journal of Pharmacology, vol. 45, no. 3, pp. 305–306, 2013. View at Publisher · View at Google Scholar
  9. Y.-Y. Yeh and L. Liu, “Cholesterol-lowering effect of garlic extracts and organosulfur compounds: human and animal studies,” Journal of Nutrition, vol. 131, no. 3, pp. 989S–993S, 2001. View at Google Scholar · View at Scopus
  10. R. B. Singh, M. A. Niaz, and S. Ghosh, “Hypolipidemic and antioxidant effects of commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia,” Cardiovascular Drugs and Therapy, vol. 8, no. 4, pp. 659–664, 1994. View at Publisher · View at Google Scholar · View at Scopus
  11. W. W. Wong, E. O'Brian Smith, J. E. Stuff, D. L. Hachey, W. C. Heird, and H. J. Pownell, “Cholesterol-lowering effect of soy protein in normocholesterolemic and hypercholesterolemic men,” The American Journal of Clinical Nutrition, vol. 68, no. 6, pp. 13855S–13895S, 1998. View at Google Scholar · View at Scopus
  12. A. M. Sabzghabaee, M. Dianatkhah, N. Sarrafzadegan, S. Asgary, and A. Ghannadi, “Clinical evaluation of Nigella sativa seeds for the treatment of hyperlipidemia: a randomized, placebo controlled clinical trial,” Medical Archives, vol. 66, no. 3, pp. 198–200, 2012. View at Publisher · View at Google Scholar
  13. R. Solà, E. Bruckert, R.-M. Valls et al., “Soluble fibre (Plantago ovata husk) reduces plasma low-density lipoprotein (LDL) cholesterol, triglycerides, insulin, oxidised LDL and systolic blood pressure in hypercholesterolaemic patients: a randomised trial,” Atherosclerosis, vol. 211, no. 2, pp. 630–637, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. R. L. Van Zyl and A. M. Viljoen, “In vitro activity of Aloe extracts against Plasmodium falciparum,” South African Journal of Botany, vol. 68, no. 1, pp. 106–110, 2002. View at Google Scholar · View at Scopus
  15. D. K. Patel, R. Kumar, D. Laloo, and S. Hemalatha, “Natural medicines from plant source used for therapy of diabetes mellitus: an overview of its pharmacological aspects,” pp. 239–250, 2012. View at Google Scholar
  16. B. Lu, D. Xia, W. Huang, X. Wu, Y. Zhang, and Y. Yao, “Hypolipidemic effect of bamboo shoot oil (P. pubescens) in Sprague-Dawley rats,” Journal of Food Science, vol. 75, no. 6, pp. H205–H211, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. N. Taleb-Dida, D. Krouf, and M. Bouchenak, “Globularia alypum aqueous extract decreases hypertriglyceridemia and ameliorates oxidative status of the muscle, kidney, and heart in rats fed a high-fructose diet,” Nutrition Research, vol. 31, no. 6, pp. 488–495, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. C. C. Allain, L. S. Poon, and C. S. G. Chan, “Enzymatic determination of total serum cholesterol,” Clinical Chemistry, vol. 20, no. 4, pp. 470–475, 1974. View at Google Scholar · View at Scopus
  19. M. Burstein, H. R. Scholnick, and R. Morfin, “Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions,” Journal of Lipid Research, vol. 11, no. 6, pp. 583–595, 1970. View at Google Scholar · View at Scopus
  20. M. W. McGowan, J. D. Artiss, D. R. Strandbergh, and B. Zak, “A peroxidase-coupled method for the colorimetric determination of serum triglycerides,” Clinical Chemistry, vol. 29, no. 3, pp. 538–542, 1983. View at Google Scholar · View at Scopus
  21. J. Sedlak and R. H. Lindsay, “Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent,” Analytical Biochemistry, vol. 25, pp. 192–205, 1968. View at Google Scholar · View at Scopus
  22. H. Ohkawa, N. Ohishi, and K. Yagi, “Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction,” Analytical Biochemistry, vol. 95, no. 2, pp. 351–358, 1979. View at Google Scholar · View at Scopus
  23. A. Venugopala Rao and S. Ramakrishnan, “Indirect assessment of hydroxymethylglutaryl CoA reductase (NADPH) activity in liver tissue,” Clinical Chemistry, vol. 21, no. 10, pp. 1523–1525, 1975. View at Google Scholar · View at Scopus
  24. A. R. Borate, A. A. Suralkar, S. S. Birje, P. V. Malusare, and P. A. Bangale, “Antihyperlipidemic effect of protocatechuic acid in fructose induced hyperlipidemia in rats,” International Journal of Pharma and Bio Sciences, vol. 2, no. 4, pp. 456–460, 2011. View at Google Scholar · View at Scopus
  25. G. L. Kelley, G. Allan, and S. Azhar, “High dietary fructose induces a hepatic stress response resulting in cholesterol and lipid dysregulation,” Endocrinology, vol. 145, no. 2, pp. 548–555, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. J. Fu, X. Zhang, K. Liu et al., “Hypolipidemic activity in Sprague-Dawley rats and constituents of a novel natural vegetable oil from Cornus wilsoniana fruits,” Journal of Food Science, vol. 77, pp. 160–169, 2012. View at Google Scholar
  27. O.-J. Park, D. Cesar, D. Faix, K. Wu, C. H. L. Shackleton, and M. K. Hellerstein, “Mechanisms of fructose-induced hypertriglyceridaemia in the rat. Activation of hepatic pyruvate dehydrogenase through inhibition of pyruvate dehydrogenase kinase,” Biochemical Journal, vol. 282, no. 3, pp. 753–757, 1992. View at Google Scholar · View at Scopus
  28. R. Yazdanparast, S. Bahramikia, and A. Ardestani, “Nasturtium officinale reduces oxidative stress and enhances antioxidant capacity in hypercholesterolaemic rats,” Chemico-Biological Interactions, vol. 172, no. 3, pp. 176–184, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. P. G. Jain, S. D. Patil, N. G. Haswani, M. V. Girase, and S. J. Surana, “Hypolipidemic activity of Moringa oleifera Lam., Moringaceae, on high fat diet induced hyperlipidemia in albino rats,” Brazilian Journal of Pharmacognosy, vol. 20, no. 6, pp. 969–973, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Valgimigli, E. Merli, P. Malagutti et al., “Endothelial dysfunction in acute and chronic coronary syndromes: evidence for a pathogenetic role of oxidative stress,” Archives of Biochemistry and Biophysics, vol. 420, no. 2, pp. 255–261, 2003. View at Publisher · View at Google Scholar · View at Scopus
  31. N. P. Visavadiya and A. V. R. L. Narasimhacharya, “Hypolipidemic and antioxidant activities of Asparagus racemosus in hypercholesteremic rats,” Indian Journal of Pharmacology, vol. 37, no. 6, pp. 376–380, 2005. View at Google Scholar · View at Scopus
  32. S. S. Reddy, P. Ramatholisamma, R. Karuna, and D. Saralakumari, “Preventive effect of Tinospora cordifolia against high-fructose diet-induced insulin resistance and oxidative stress in male Wistar rats,” Food and Chemical Toxicology, vol. 47, no. 9, pp. 2224–2229, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. T. D'Souza, S. Mengi, S. Hassarajani, and S. Chattopadhayay, “Efficacy study of the bioactive fraction (F-3) of Acorus calamus in hyperlipidemia,” Indian Journal of Pharmacology, vol. 39, no. 4, pp. 196–200, 2007. View at Google Scholar · View at Scopus
  34. P. O. Bonetti, D. R. Holmes Jr., A. Lerman, and G. W. Barsness, “Enhanced external counterpulsation for ischemic heart disease: what's behind the curtain?” Journal of the American College of Cardiology, vol. 41, no. 11, pp. 1918–1925, 2003. View at Publisher · View at Google Scholar · View at Scopus
  35. L. K. Mehta, R. Balaraman, A. H. Amin, P. A. Bafna, and O. D. Gulati, “Effect of fruits of Moringa oleifera on the lipid profile of normal and hypercholesterolaemic rabbits,” Journal of Ethnopharmacology, vol. 86, no. 2-3, pp. 191–195, 2003. View at Publisher · View at Google Scholar · View at Scopus