Oral Cavity as an Extragastric Reservoir of Helicobacter pylori

Table 8

Data regarding effects of periodontal therapy on H. pylori in dental plaque and gastric infection.

No.	Authors	Year	Method used to detect H. pylori	Sample size	Prevalence of H. pylori	Prevalence after anti-H. pylori therapy	Effect on H. pylori infection
1	Gao et al. [44]	2011	PCR-ureC and cagA genes	80 patients with H. pylori infection-37 treated with anti-HP therapy (gp A) and 43 treated with anti-H. pylori therapy and periodontal therapy (gp B)		After 4 weeks-29.7% in gp A and 4.7% in gp B; after 1 year-43.2% in gp A and 18.6% in gp B	Eradication rate of gastric H. pylori. After 4 weeks-73% in gp A and 81.4% in gp B, After 1 year-32.4% in gp A and 62.8% in gp B
2	Zaric et al. [40]	2009	PCR	43 patients positive for H. pylori in sub gingival dental plaque and gastric mucosa: 21 received only anti-H. pylori triple therapy (G^+O^+t); 22 received anti-H. pylori triple therapy + periodontal therapy (G^+O^+tp)		In G^+O^+t-66.7%; in G^+O^+tp-27.3%	In the G^+O^+tp group, 77.3% showed eradication of gastric H. pylori compared to 47.6% in G^+O^+t. H. pylori eradication in the stomach and the oral cavity coincided—that is, all 16 of the individuals negative for oral H. pylori were also negative for gastric H. pylori. Five of the participants positive for oral samples were positive for gastric H. pylori as well.
3	Jia et al. [47]	2009		107 dyspeptic patients-56 received dental plaque control (test) and 51 did not (control)			Prevalence of H. pylori in gastric mucosa was 19.64% in test group and 84.31% in control group
4	Butt et al. [46]	2001	Smear cytology	82 patients positive for H. pylori in dental plaque: 27 received only anti-H. pylori therapy (gp 1); 25 received anti-H. pylori therapy + periodontal therapy (gp 2); 30 received only periodontal therapy (gp 3)	100%	100% in gp 1; 16% in gp 2; 10% in gp 3