Table of Contents
ISRN Hematology
Volume 2014, Article ID 293216, 5 pages
Research Article

Coexisting Iron Deficiency Anemia and Beta Thalassemia Trait: Effect of Iron Therapy on Red Cell Parameters and Hemoglobin Subtypes

1Department of Pathology, Hindu Rao Hospital, Malka Ganj, Delhi 110007, India
2Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
3Department of Pediatrics, Hindu Rao Hospital, Malka Ganj, Delhi 110007, India
4Department of Medicine, Hindu Rao Hospital, Malka Ganj, Delhi 110007, India

Received 26 November 2013; Accepted 16 January 2014; Published 12 March 2014

Academic Editors: A. Gatt and H. Knecht

Copyright © 2014 Sarika Verma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Coexistence of iron deficiency anemia (IDA) and beta thalassemia trait (BTT) has been the topic of few studies. However, no study from our country was found evaluating the effect of iron therapy in patients with concomitant IDA and BTT. Methods. Over a period of two years, 30 patients with concomitant IDA and BTT were included. All the patients had a complete blood count, serum iron studies, and thalassemia screening using BIORADTM hemoglobin testing system. The patients received oral iron therapy in appropriate dosages for a period of twenty weeks, after which all the investigations were repeated. Appropriate statistical methods were applied for comparison of pre- and posttherapy data. Results. All except two patients were adults with a marked female preponderance. Oral iron therapy led to statistically significant improvement in hemoglobin, red cell indices ( ), and marked change in serum iron, ferritin, and HbA2 levels ( ). There was a significant reduction in the total iron binding capacity levels. Conclusion. The present study shows the frequent occurrence of iron deficiency anemia in patients with beta thalassemia trait, which can potentially confound the diagnosis of the latter. Hence, iron deficiency should be identified and rectified in patients with suspicion of beta thalassemia trait.