|
| Trial | Patient number |
SC dose
(million) | Followup
(months) | Time to PCI (hours) |
SC delivery
Time (days) |
LVEF method |
| BMSC/Placebo | BMSC |
Placebo |
|
| Short term | Wollert et al., 2004 BOOST [6] | 30/30 | 2460 (940) | 6 | 9.8 (2.0–22)* | 8.0 (3.0–120)* | 4.8 (1.3) | MRI |
| Chen et al., 2004 [9] | 34/35 | (8000–10000)* | 6 | 8.3 (3.8) | 8.5 (3.9) | 18.4 (0.5) | Angio/PET |
| Janssens et al., 2006 [2] | 33/34 | 172 (72) | 4 | 3.7 (2.5–7.6)* | 4.1 (3.1–8.3)* | <1.0 | MRI |
|
Schächinger et al., 2006 REPAIR-AMI [8] | 95/92 | 236 (174) | 4 | 4.5* | 4.5* | 4.3 (1.3) | Angio/PET |
| Ge et al., 2006 TCT-STAMI [10] | 10/10 | 38.7 (21.6) | 6 | 7.9 (3.8) | 7.1 (3.1) | <1.0 | Echo |
| Lunde et al., 2006 ASTAMI [3] | 45/44 | 87.1 (47.7) | 6 | 3.5 (3.0–5.5)* | 3.8 (3.0–5.5)* | 6.0 (4.0–7.0)* | MRI |
| Meluzín et al., 2008 [16] | 20/20 | 100 (90–200)* | 6 | 7.2 (2.7) | 9.2 (3.4) | 6.8 (0.3) | Echo |
| Penicka et al., 2007 +++++ [17] | 14/10 | 2640 (1960–3300) | 4 | 5.2 (5.0–11)* | 5.2 (5.0–11)* | 9.0 (4.0–11)* | Echo |
| Tendera et al., 2009 REGENT [4] | 80/40 | 178 | 6 | 5.2 (2.0–16.7)* | 5.0 (2.0–22)* | 7.0 (3.0–12)* | MRI |
| Plewka et al., 2009 [12] | 38/18 | 144 (49) | 6 | 7.0 (2.0) | 8.0 (3.0) | 7.0 (2.0) | Echo |
| Grajek et al., 2010 [5] | 31/14 | 410 (180) | 6 | 4.8 (3.9) | 3.2 (3.5) | (4.0–6.0)* | Echo |
| Piepoli et al., 2010 [18] | 19/19 | 418 | 6 | 4.1 (1.1) | 4.4 (0.6) | 4.0 (1.0) | Angio/PET |
| Traverse et al., 2010 [19] | 30/10 | 100 | 6 | 6.5 (4.3) | 2.9 (2.8–10.6)* | 5.2 (2.3) | MRI |
|
| Long term | Meyer et al., 2006 BOOST [20] | 30/30 | 2460 (940) | 18 | 9.8 (2.0–22)* | 8.0 (3.0–120)* | 4.8 (1.3) | MRI |
| Meluzín et al., 2008 [16] | 20/20 | 100 (90–200)* | 12 | 7.2 (2.7) | 9.2 (3.4) | 6.8 (0.3) | Echo |
| Beitnes et al., 2009 ASTAMI [21] | 50/50 | 68 (54–130)* | 36 | 3.5 (3.0–5.5)* | 3.8 (3.0–5.5)* | 6.0 (4.0–7.0)* | MRI |
| Yousef et al., 2009 BALANCE [22] | 62/62 | 61 (39) | 60 | 10 (9.0) | 10 (9.0) | 7.0 (2.0) | Angio/PET |
| Grajek et al., 2010 [5] | 31/14 | 410 (180) | 12 | 4.8 (3.9) | 3.2 (3.5) | (4.0–6.0)* | Echo |
| Assmus et al., 2010 REPAIR-AMI CMR-Subs [23] | 26/33 | 236 (174) | 12 | 7.5 (8.0) | 7.0 (6.5) | 4.4 (1.4) | MRI |
| Piepoli et al., 2010 [18] | 19/19 | 418 | 12 | 4.1 (1.1) | 4.4 (0.6) | 4.0 (1.0) | Angio/PET |
|
