Table of Contents
ISRN Orthopedics
Volume 2014 (2014), Article ID 314137, 10 pages
http://dx.doi.org/10.1155/2014/314137
Review Article

Treatment Options for Brachial Plexus Injuries

1Department of Orthopaedic Surgery, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA
2Department of Orthopaedic Surgery, General Hospital of Levadia, 32100 Levadia, Greece
31st Department of Orthopedic Surgery, Athens University Medical School, Attikon University General Hospital, Chaidari, 12462 Athens, Greece

Received 14 November 2013; Accepted 8 January 2014; Published 14 April 2014

Academic Editors: K. Akeda and J. Dubousset

Copyright © 2014 Vasileios I. Sakellariou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. V. Bentolila, R. Nizard, P. Bizot, and L. Sedel, “Complete traumatic brachial plexus palsy. Treatment and outcome affer repair,” Journal of Bone and Joint Surgery A, vol. 81, no. 1, pp. 20–28, 1999. View at Google Scholar · View at Scopus
  2. H. Millesi, “Brachial plexus injuries. Nerve grafting,” Clinical Orthopaedics and Related Research, no. 237, pp. 36–42, 1988. View at Google Scholar · View at Scopus
  3. H. Millesi, “Interfascicular grafts for repair of peripheral nerves of the upper extremity,” Orthopedic Clinics of North America, vol. 8, no. 2, pp. 387–404, 1977. View at Google Scholar · View at Scopus
  4. A. Nagano, N. Tsuyama, N. Ochiai, T. Hara, and M. Takahashi, “Direct nerve crossing with the intercostal nerve to treat avulsion injuries of the brachial plexus,” Journal of Hand Surgery A, vol. 14, no. 6, pp. 980–985, 1989. View at Google Scholar · View at Scopus
  5. M. Samii, G. A. Carvalho, G. Nikkhah, and G. Penkert, “Surgical reconstruction of the musculocutaneous nerve in traumatic brachial plexus injuries,” Journal of Neurosurgery, vol. 87, no. 6, pp. 881–886, 1997. View at Google Scholar · View at Scopus
  6. P. Songcharoen, B. Mahaisavariya, and C. Chotigavanich, “Spinal accessory neurotization for restoration of elbow flexion in avulsion injuries of the brachial plexus,” Journal of Hand Surgery A, vol. 21, no. 3, pp. 387–390, 1996. View at Publisher · View at Google Scholar · View at Scopus
  7. A. S. Dubuisson and D. G. Kline, “Brachial plexus injury: a survey of 100 consecutive cases from a single service,” Neurosurgery, vol. 51, no. 3, pp. 673–683, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Nagano, “Treatment of brachial plexus injury,” Journal of Orthopaedic Science, vol. 3, no. 1, pp. 71–80, 1998. View at Publisher · View at Google Scholar · View at Scopus
  9. Y. Gu, J. Xu, L. Chen, H. Wang, and S. Hu, “Long-term outcome of contralateral C7 transfer: a report of 32 cases,” Chinese Medical Journal, vol. 115, no. 6, pp. 866–868, 2002. View at Google Scholar · View at Scopus
  10. J. Berman, P. Anand, L. Chen, M. Taggart, and R. Birch, “Pain relief from preganglionic injury to the brachial plexus by late intercostal nerve transfer,” Journal of Bone and Joint Surgery B, vol. 78, no. 5, pp. 759–760, 1996. View at Google Scholar · View at Scopus
  11. J. L. Giuffre, S. Kakar, A. T. Bishop, R. J. Spinner, and A. Y. Shin, “Current concepts of the treatment of adult brachial plexus injuries,” Journal of Hand Surgery A, vol. 35, no. 4, pp. 678–688, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Hattori, K. Doi, S. Sakamoto, and K. Yukata, “Sensory recovery of the hand with intercostal nerve transfer following complete avulsion of the brachial plexus,” Plastic and Reconstructive Surgery, vol. 123, no. 1, pp. 276–283, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. D. G. Kline, “Civilian gunshot wounds to the brachial plexus,” Journal of Neurosurgery, vol. 70, no. 2, pp. 166–174, 1989. View at Google Scholar · View at Scopus
  14. R. D. Leffert, “Brachial plexus injuries in the adult,” in Orthopaedic Knowledge Update: Shoulder and Elbow 2, T. R. Norris, Ed., Journal of the American Academy of Orthopaedic Surgeons, 394, 2002. View at Google Scholar
  15. B. S. Nashold Jr., “Current status of the DREZ operation,” Neurosurgery, vol. 15, no. 6, pp. 942–944, 1984. View at Google Scholar · View at Scopus
  16. S. J. Jones, C. B. Parry, and A. Landi, “Diagnosis of brachial plexus traction lesions by sensory nerve action potentials and somatosensory evoked potentials,” Injury, vol. 12, no. 5, pp. 376–382, 1981. View at Google Scholar · View at Scopus
  17. V. M. Synek and J. C. Cowan, “Somatosensory evoked potentials in patients with supraclavicular brachial plexus injuries,” Neurology, vol. 32, no. 12, pp. 1347–1352, 1982. View at Google Scholar · View at Scopus
  18. E. Turkof, H. Millesi, R. Turkof, P. Pfundner, and N. Mayr, “Intraoperative electroneurodiagnostics (transcranial electrical motor evoked potentials) to evaluate the functional status of anterior spinal roots and spinal nerves during brachial plexus surgery,” Plastic and Reconstructive Surgery, vol. 99, no. 6, pp. 1632–1641, 1997. View at Google Scholar · View at Scopus
  19. E. Turkof, J. Monsivais, I. Dechtyar, H. Bellolo, H. Millesi, and N. Mayr, “Motor evoked potential as a reliable method to verify the conductivity of anterior spinal roots in brachial plexus surgery: an experimental study on goats,” Journal of Reconstructive Microsurgery, vol. 11, no. 5, pp. 357–362, 1995. View at Google Scholar · View at Scopus
  20. D. C. Chuang, M. D. Epstein, M. C. Yeh, and F. C. Wei, “Functional restoration of elbow flexion in brachial plexus injuries: results in 167 patients (excluding obstetric brachial plexus injury),” Journal of Hand Surgery A, vol. 18, no. 2, pp. 285–291, 1993. View at Google Scholar · View at Scopus
  21. V. R. Hentz and A. Narakas, “The results of microneurosurgical reconstruction in complete brachial plexus palsy. Assessing outcome and predicting results,” Orthopedic Clinics of North America, vol. 19, no. 1, pp. 107–114, 1988. View at Google Scholar · View at Scopus
  22. N. Ochiai, A. Nagano, H. Sugioka, and T. Hara, “Nerve grafting in brachial plexus injuries,” Journal of Bone and Joint Surgery B, vol. 78, no. 5, pp. 754–758, 1996. View at Google Scholar · View at Scopus
  23. G. I. Taylor and F. J. Ham, “The free vascularized nerve graft. A further experimental and clinical application of microvascular techniques,” Plastic and Reconstructive Surgery, vol. 57, no. 4, pp. 413–425, 1976. View at Google Scholar · View at Scopus
  24. D. Eberhard and H. Millesi, “Split nerve grafting,” Journal of Reconstructive Microsurgery, vol. 12, pp. 71–76, 1994. View at Google Scholar
  25. R. Birch, M. Dunkerton, G. Bonney, and A. M. Jamieson, “Experience with the free vascularized ulnar nerve graft in repair of supraclavicular lesions of the brachial plexus,” Clinical Orthopaedics and Related Research, no. 237, pp. 96–104, 1988. View at Google Scholar · View at Scopus
  26. C. Oberlin, D. Beal, S. Leechavengvongs, A. Salon, M. C. Dauge, and J. J. Sarcy, “Nerve transfer to biceps muscle using a part of ulnar nerve for C5-C6 avulsion of the brachial plexus: anatomical study and report of four cases,” Journal of Hand Surgery A, vol. 19, no. 2, pp. 232–237, 1994. View at Google Scholar · View at Scopus
  27. G. A. Merrell, K. A. Barrie, D. L. Katz, and S. W. Wolfe, “Results of nerve transfer techniques for restoration of shoulder and elbow function in the context of a meta-analysis of the English literature,” Journal of Hand Surgery A, vol. 26, no. 2, pp. 303–314, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Leechavengvongs, K. Witoonchart, C. Uerpairojkit, P. Thuvasethakul, and W. Ketmalasiri, “Nerve transfer to biceps muscle using a part of the ulnar nerve in brachial plexus injury (upper arm type): a report of 32 cases,” Journal of Hand Surgery A, vol. 23, no. 4, pp. 711–716, 1998. View at Google Scholar · View at Scopus
  29. A. Sungpet, C. Suphachatwong, V. Kawinwonggowit, and A. Patradul, “Transfer of a single fascicle from the ulnar nerve to the biceps muscle after avulsions of upper roots of the brachial plexus,” Journal of Hand Surgery B, vol. 25, no. 4, pp. 325–328, 2000. View at Publisher · View at Google Scholar · View at Scopus
  30. Y. Allieu and P. Cenac, “Neurotization via the spinal accessory nerve in complete paralysis due to multiple avulsion injuries of the brachial plexus,” Clinical Orthopaedics and Related Research, no. 237, pp. 67–74, 1988. View at Google Scholar · View at Scopus
  31. W. Z. Ray, R. K. J. Murphy, K. Santosa, P. J. Johnson, and S. E. Mackinnon, “Medial pectoral nerve to axillary nerve neurotization following traumatic brachial plexus injuries: indications and clinical outcomes,” Hand, vol. 7, no. 1, pp. 59–65, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. Y. D. Gu, M. M. Wu, Y. L. Zhen et al., “Phrenic nerve transfer for brachial plexus motor neurotization,” Microsurgery, vol. 10, no. 4, pp. 287–289, 1989. View at Google Scholar · View at Scopus
  33. P. Songcharoen, S. Wongtrakul, B. Mahaisavariya, and R. J. Spinner, “Hemi-contralateral C7 transfer to median nerve in the treatment of root avulsion brachial plexus injury,” Journal of Hand Surgery A, vol. 26, no. 6, pp. 1058–1064, 2001. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Waikakul, S. Orapin, and V. Vanadurongwan, “Clinical results of contralateral C7 root neurotization to the median nerve in brachial plexus injuries with total root avulsions,” Journal of Hand Surgery B, vol. 24, no. 5, pp. 556–560, 1999. View at Publisher · View at Google Scholar · View at Scopus
  35. D. C. Chuang, S. L. Cheng, F. C. Wei, C. L. Wu, and Y. S. Ho, “Clinical evaluation of C7 spinal nerve transection: 21 patients with at least 2 years' follow-up,” The British Journal of Plastic Surgery, vol. 51, no. 4, pp. 285–290, 1998. View at Google Scholar
  36. A. E. Price and J. A. I. Grossman, “A management approach for secondary shoulder and forearm deformities following obstetrical brachial plexus injury,” Hand Clinics, vol. 11, no. 4, pp. 607–617, 1995. View at Google Scholar · View at Scopus
  37. K. Witoonchart, S. Leechavengvongs, C. Uerpairojkit, P. Thuvasethakul, and V. Wongnopsuwan, “Nerve transfer to deltoid muscle using the nerve to the long head of the triceps—part I: an anatomic feasibility study,” Journal of Hand Surgery A, vol. 28, no. 4, pp. 628–632, 2003. View at Publisher · View at Google Scholar · View at Scopus
  38. S. Leechavengvongs, K. Witoonchart, C. Uerpairojkit, and P. Thuvasethakul, “Nerve transfer to deltoid muscle using the nerve to the long head of the triceps—part II: a report of 7 cases,” Journal of Hand Surgery A, vol. 28, no. 4, pp. 633–638, 2003. View at Publisher · View at Google Scholar · View at Scopus
  39. J. K. Terzis, M. D. Vekris, and P. N. Soucacos, “Outcomes of brachial plexus reconstruction in 204 patients with devastating paralysis,” Plastic and Reconstructive Surgery, vol. 104, no. 5, pp. 1221–1240, 1999. View at Publisher · View at Google Scholar · View at Scopus
  40. F. Viterbo, J. C. Trindade, K. Hoshino, and A. M. Neto, “End-to-side neurorrhaphy with removal of the epineurial sheath: an experimental study in rats,” Plastic and Reconstructive Surgery, vol. 94, no. 7, pp. 1038–1047, 1994. View at Google Scholar · View at Scopus
  41. E. Rouholamin, J. R. Wootton, and A. M. Jamieson, “Arthrodesis of the shoulder following brachial plexus injury,” Injury, vol. 22, no. 4, pp. 271–274, 1991. View at Publisher · View at Google Scholar · View at Scopus
  42. B. Elhassan, A. Bishop, A. Shin, and R. Spinner, “Shoulder tendon transfer options for adult patients with brachial plexus injury,” Journal of Hand Surgery A, vol. 35, no. 7, pp. 1211–1219, 2010. View at Publisher · View at Google Scholar · View at Scopus
  43. A. M. Hendry, “The treatment of residual paralysis after brachial plexus injuries,” Journal of Bone and Joint Surgery B, vol. 31, no. 1, pp. 42–49, 1949. View at Google Scholar · View at Scopus
  44. R. R. . Richards, “Operative treatment for irreparable lesions of the brachial plexus,” in Operative Nerve Repair and Reconstruction, R. H. Gelberman, Ed., pp. 1303–1327, J. B. Lippincott & Company, Philadelphia, Pa, USA, 1991. View at Google Scholar
  45. A. Steindler, “Operative reconstruction work on hand and forearm,” New York Medical Journal, vol. 108, pp. 1117–1119, 1918. View at Google Scholar
  46. R. Tubiana, “Clinical examination and functional assessment of the upper limb after peripheral nerve lesions,” in The Hand, R. Tubiana, Ed., pp. 453–488, WB Saunders, Philadelphia, Pa, USA, 1988. View at Google Scholar
  47. R. E. Carroll and N. A. Hill, “Triceps transfer to restore elbow flexion. A study of fifteen patients with paralytic lesions and arthrogryposis,” Journal of Bone and Joint Surgery A, vol. 52, no. 2, pp. 239–244, 1970. View at Google Scholar · View at Scopus
  48. D. C. Chuang, “Neurotization procedures for brachial plexus injuries,” Hand Clinics, vol. 11, no. 4, pp. 633–646, 1995. View at Google Scholar · View at Scopus
  49. D. C. Chuang, G. W. Lee, F. Hashem, and F. C. Wei, “Restoration of shoulder abduction by nerve transfer in avulsed brachial plexus injury: evaluation of 99 patients with various nerve transfers,” Plastic and Reconstructive Surgery, vol. 96, no. 1, pp. 122–128, 1995. View at Google Scholar · View at Scopus
  50. J. D. Krakauer and M. B. Wood, “Intercostal nerve transfer for brachial plexopathy,” Journal of Hand Surgery A, vol. 19, no. 5, pp. 829–835, 1994. View at Google Scholar · View at Scopus
  51. Y. Mikami, A. Nagano, N. Ochiai, and S. Yamamoto, “Results of nerve grafting for injuries of the axillary and suprascapular nerves,” Journal of Bone and Joint Surgery B, vol. 79, no. 4, pp. 527–531, 1997. View at Publisher · View at Google Scholar · View at Scopus
  52. A. O. Narakas and V. R. Hentz, “Neurotization in brachial plexus injuries: indication and results,” Clinical Orthopaedics and Related Research, no. 237, pp. 43–56, 1988. View at Google Scholar · View at Scopus
  53. D. S. Ruch, A. Friedman, and J. A. Nunley, “The restoration of elbow flexion with intercostal nerve transfers,” Clinical Orthopaedics and Related Research, no. 314, pp. 95–103, 1995. View at Google Scholar · View at Scopus
  54. D. M. Stewart, O. M. Sola, and A. W. Martin, “Hypertrophy as a response to denervation in skeletal muscle,” Zeitschrift für Vergleichende Physiologie, vol. 76, no. 2, pp. 146–167, 1972. View at Publisher · View at Google Scholar · View at Scopus
  55. S. Sunderland and L. J. Ray, “Denervation changes in mammalian striated muscle,” Journal of Neurology, Neurosurgery and Psychiatry, vol. 13, no. 3, pp. 159–177, 1950. View at Google Scholar
  56. Y. Akasaka, T. Hara, and M. Takahashi, “Free muscle transplantation combined with intercostal nerve crossing for reconstruction of elbow flexion and wrist extension in brachial plexus injuries,” Microsurgery, vol. 12, no. 5, pp. 346–351, 1991. View at Publisher · View at Google Scholar · View at Scopus
  57. K. A. Barrie, S. P. Steinmann, A. Y. Shin, R. J. Spinner, and A. T. Bishop, “Gracilis free muscle transfer for restoration of function after complete brachial plexus avulsion,” Neurosurg Focus, vol. 16, no. 5, article E8, 2004. View at Google Scholar · View at Scopus
  58. A. Berger, P.-J. Flory, and E. Schaller, “Muscle transfers in brachial plexus lesions,” Journal of Reconstructive Microsurgery, vol. 6, no. 2, pp. 113–116, 1990. View at Google Scholar · View at Scopus
  59. K. Doi, K. Sakai, N. Kuwata, K. Ihara, and S. Kawai, “Reconstruction of finger and elbow function after complete avulsion of the brachial plexus,” Journal of Hand Surgery A, vol. 16, no. 5, pp. 796–803, 1991. View at Google Scholar · View at Scopus
  60. K. Doi, Y. Hattori, N. Kuwata et al., “Free muscle transfer can restore hand function after injuries of the lower brachial plexus,” Journal of Bone and Joint Surgery B, vol. 80, no. 1, pp. 117–120, 1998. View at Publisher · View at Google Scholar · View at Scopus
  61. K. Doi, K. Sakai, Y. Fuchigami, and S. Kawai, “Reconstruction of irreparable brachial plexus injuries with reinnervated free-muscle transfer: case report,” Journal of Neurosurgery, vol. 85, no. 1, pp. 174–177, 1996. View at Google Scholar · View at Scopus
  62. K. Doi, K. Sakai, N. Kuwata, K. Ihara, and S. Kawai, “Double free-muscle transfer to restore prehension following complete brachial plexus avulsion,” Journal of Hand Surgery A, vol. 20, no. 3 I, pp. 408–414, 1995. View at Publisher · View at Google Scholar · View at Scopus
  63. R. T. Manktelow, “Functioning muscle transplantation to the upper limb,” Clinics in Plastic Surgery, vol. 11, no. 1, pp. 59–63, 1984. View at Google Scholar · View at Scopus
  64. Y. Akasaka, T. Hara, and M. Takahashi, “Restoration of elbow flexion and wrist extension in brachial plexus paralyses by means of free muscle transplantation innervated by intercostal nerve,” Annales de Chirurgie de la Main et du Membre Superieur, vol. 9, no. 5, pp. 341–350, 1990. View at Google Scholar · View at Scopus
  65. D. C. Chuang, “Functioning free muscle transplantation for brachial plexus injury,” Clinical Orthopaedics and Related Research, no. 314, pp. 104–111, 1995. View at Google Scholar · View at Scopus
  66. D. C. Chuang, N. Carver, and F. C. Wei, “Results of functioning free muscle transplantation for elbow flexion,” Journal of Hand Surgery A, vol. 21, no. 6, pp. 1071–1077, 1996. View at Publisher · View at Google Scholar · View at Scopus
  67. A. Sungpet, C. Suphachatwong, and V. Kawinwonggowit, “Transfer of one fascicle of ulnar nerve to functioning free gracilis muscle transplantation for elbow flexion,” Australian and New Zealand Journal of Surgery, vol. 73, no. 3, pp. 133–135, 2003. View at Publisher · View at Google Scholar · View at Scopus
  68. K. J. Favero, M. B. Wood, and N. B. Meland, “Transfer of innervated latissimus dorsi free musculocutaneous flap for the restoration of finger flexion,” Journal of Hand Surgery A, vol. 18, no. 3, pp. 535–540, 1993. View at Google Scholar · View at Scopus
  69. A. P. Hovnanian, “Latissimus dorsi transplantation for loss of flexion or extension at the elbow,” Annals of Surgery, vol. 143, no. 4, pp. 494–499, 1956. View at Google Scholar
  70. K. Ihara, M. Shigetomi, S. Kawai, K. Doi, and M. Yamamoto, “Functioning muscle transplantation after wide excision of sarcomas in the extremity,” Clinical Orthopaedics and Related Research, no. 358, pp. 140–148, 1999. View at Google Scholar · View at Scopus
  71. L. Lu, X. Gong, Z. Liu, D. Wang, and Z. Zhang, “Diagnosis and operative treatment of radiation-induced brachial plexopathy,” Chinese Journal of Traumatology, vol. 5, no. 6, pp. 329–332, 2002. View at Google Scholar · View at Scopus
  72. H. Takami, S. Takahashi, and M. Ando, “Latissimus dorsi transplantation to restore elbow flexion to the paralysed limb,” Journal of Hand Surgery B, vol. 9, no. 1, pp. 61–63, 1984. View at Google Scholar · View at Scopus
  73. A. S. Baliarsing, K. Doi, and Y. Hattori, “Bilateral elbow flexion reconstruction with functioning free muscle transfer for obstetric brachial plexus palsy,” Journal of Hand Surgery B, vol. 27, no. 5, pp. 484–486, 2002. View at Publisher · View at Google Scholar · View at Scopus
  74. K. Doi, K. Sakai, K. Ihara, Y. Abe, S. Kawai, and Y. Kurafuji, “Reinnervated free muscle transplantation for extremity reconstruction,” Plastic and Reconstructive Surgery, vol. 91, no. 5, pp. 872–883, 1993. View at Google Scholar · View at Scopus
  75. A. H. Friedman, J. A. Nunley II, R. D. Goldner, W. J. Oakes, J. L. Goldner, and J. R. Urbaniak, “Nerve transposition for the restoration of elbow flexion following brachial plexus avulsion injuries,” Journal of Neurosurgery, vol. 72, no. 1, pp. 59–64, 1990. View at Google Scholar · View at Scopus
  76. Y. Hattori, K. Doi, R. Ohi, S. Fukushima, and A. S. Baliarsing, “Clinical application of intraoperative measurement of choline acetyltransferase activity during functioning free muscle transfer,” Journal of Hand Surgery A, vol. 26, no. 4, pp. 645–648, 2001. View at Publisher · View at Google Scholar · View at Scopus
  77. Y. Ikuta, K. Yoshioka, and K. Tsuge, “Free muscle graft as applied to brachial plexus injury—case report and experimental study,” Annals of the Academy of Medicine Singapore, vol. 8, no. 4, pp. 454–458, 1979. View at Google Scholar · View at Scopus
  78. C. Oberlin, “Brachial plexus palsy in the adult: a systematic approach to root lesions,” Chirurgie de la Main, vol. 22, no. 6, pp. 273–284, 2003. View at Publisher · View at Google Scholar · View at Scopus
  79. K. Doi, “New reconstructive procedure for brachial plexus injury,” Clinics in Plastic Surgery, vol. 24, no. 1, pp. 75–85, 1997. View at Google Scholar · View at Scopus
  80. K. Doi, K. Muramatsu, Y. Hattori et al., “Restoration of prehension with the double free muscle technique following complete avulsion of the brachial plexus. Indications and long-term results,” Journal of Bone and Joint Surgery A, vol. 82, no. 5, pp. 652–666, 2000. View at Google Scholar · View at Scopus
  81. K. Doi, N. Kuwata, K. Muramatsu, Y. Hottori, and S. Kawai, “Double muscle transfer for upper extremity reconstruction following complete avulsion of the brachial plexus,” Hand Clinics, vol. 15, no. 4, pp. 757–767, 1999. View at Google Scholar · View at Scopus
  82. A. J. Aguayo, S. David, and G. M. Bray, “Influences of the glial environment on the elongation of axons after injury: transplantation studies in adult rodents,” Journal of Experimental Biology, vol. 95, pp. 231–240, 1981. View at Google Scholar · View at Scopus
  83. A. J. Aguayo, S. David, P. Richardson, and G. M. Bray, “Axonal regeneration in peripheral and central nervous system transplants,” Advances in Cellular Neurobiology, vol. 3, pp. 215–234, 1982. View at Publisher · View at Google Scholar
  84. S. David and A. J. Aguayo, “Axonal elongation into peripheral nervous system “bridges” after central nervous system injury in adult rats,” Science, vol. 214, no. 4523, pp. 931–933, 1981. View at Google Scholar · View at Scopus
  85. P. M. Richardson, V. M. K. Issa, and A. J. Aguayo, “Regeneration of long spinal axons in the rat,” Journal of Neurocytology, vol. 13, no. 1, pp. 165–182, 1984. View at Google Scholar · View at Scopus
  86. P. M. Richardson, U. M. McGuinness, and A. J. Aguayo, “Peripheral nerve autografts to the rat spinal cord: studies with axonal tracing methods,” Brain Research, vol. 237, no. 1, pp. 147–162, 1982. View at Publisher · View at Google Scholar · View at Scopus
  87. H. Chai, W. Wu, K. So, and H. K. Yip, “Survival and regeneration of motoneurons in adult rats by reimplantation of ventral root following spinal root avulsion,” NeuroReport, vol. 11, no. 6, pp. 1249–1252, 2000. View at Google Scholar · View at Scopus
  88. C. H. Frazier and P. G. Skillern, “Supraclavicular subcutaneous lesions of the brachial plexus not associated with skeletal injuries,” The Journal of the American Medical Association, vol. 57, no. 25, pp. 1957–1963, 1911. View at Publisher · View at Google Scholar
  89. G. Bonney and A. Jamieson, “Reimplantation of C7 and C8. Communication au symposium sur le plexus brachial,” International Microsurgery, vol. 1, pp. 103–106, 1979. View at Google Scholar
  90. T. Carlstedt, P. Grane, R. G. Hallin, and G. Noren, “Return of function after spinal cord implantation of avulsed spinal nerve roots,” The Lancet, vol. 346, no. 8986, pp. 1323–1325, 1995. View at Google Scholar · View at Scopus
  91. T. Carlstedt, P. Anand, R. Hallin, P. V. Misra, G. Norén, and T. Seeferlis, “Spinal nerve root repair and reimplantation of avulsed ventral roots into the spinal cord after brachial plexus injury,” Journal of Neurosurgery, vol. 93, no. 2, pp. 237–247, 2000. View at Google Scholar · View at Scopus
  92. J. A. Friedman, A. J. Windebank, M. J. Moore, R. J. Spinner, B. L. Currier, and M. J. Yaszemski, “Biodegradable polymer grafts for surgical repair of the injured spinal cord,” Neurosurgery, vol. 51, no. 3, pp. 742–752, 2002. View at Publisher · View at Google Scholar · View at Scopus