Table of Contents
ISRN Pharmacology
Volume 2014, Article ID 327606, 8 pages
http://dx.doi.org/10.1155/2014/327606
Research Article

Gastroprotective Effect of Freeze Dried Stripped Snakehead Fish (Channa striata Bloch.) Aqueous Extract against Aspirin Induced Ulcerogenesis in Pylorus Ligated Rats

1Pharmacology & Toxicology Laboratory, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor Darul Ehsan, Malaysia
2Natural Products Research Laboratory and Department of Pharmacology, Anwarul Uloom College of Pharmacy, New Mallepally, Hyderabad, Andhra Pradesh 500 001, India
3Department of Pharmacology & Toxicology, College of Veterinary Science, Acharya N.G. Ranga Agricultural University, Rajendra Nagar, Hyderabad, Andhra Pradesh 500 030, India
4Department of Pathology, College of Veterinary Science, Acharya N.G. Ranga Agricultural University, Rajendra Nagar, Hyderabad, Andhra Pradesh 500 030, India

Received 8 January 2014; Accepted 2 March 2014; Published 29 May 2014

Academic Editors: H. Cerecetto, V. Manju, and S. Mingmalairak

Copyright © 2014 Mohammed Safwan Ali Khan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Channa striata (Bloch.) is a fresh water fish belonging to the family Channidae. The stripped snakehead fish possesses wide range of medicinal properties. In view of traditional use of C. striata for wound healing, the present study was undertaken to investigate the beneficial effects of orally administered freeze dried aqueous extract of Channa striata (AECS) in experimentally induced gastric ulcers in Wistar rats. Aspirin induced ulcerogenesis in pyloric ligation model was used for the assessment of antiulcer activity and Ranitidine (50 mg/kg) was employed as the standard drug. The various gastric parameters like volume of gastric juice, pH, free and total acidities, ulcer index, and levels of antioxidant enzymes like catalase, superoxide dismutase, and lipid peroxidation marker malondialdehyde were determined. AECS at concentrations of 40% and 50% w/v significantly decreased the volume of gastric juice and increased the levels of catalase while considerable decrease in free and total acidities and increase in superoxide dismutase were observed with the treatment of standard drug and AECS (50% w/v). All the test doses of AECS markedly decreased ulcer index and malondialdehyde compared to the standard drug whereas AECS 30% w/v did not alter volume of gastric juice, pH, free and total acidities, catalase, and superoxide dismutase. From these findings, it can be concluded that AECS is devoid of acid neutralizing effects at lower doses and possesses antisecretory and antiulcer activities and this could be related to its antioxidant mechanism.