International Scholarly Research Notices / 2014 / Article / Fig 1

Research Article

p16 Expression Is Lost in Severely Atypical Cellular Blue Nevi and Melanoma Compared to Conventional, Mildly, and Moderately Atypical Cellular Blue Nevi

Figure 1

p16 staining intensity (a) and percentage of melanocytes stained with p16 (b) and Ki-67 (c) in conventional benign and atypical nevi, CBN, melanoma, and malignant CBN. (a, b) p16 staining was higher in all CBN when compared to melanoma ( and ) and malignant CBN ( and ). Upon subclassifying the CBN based on degree of atypia, a significant increase in p16 staining in benign/mildly atypical CBN ( ) and moderately atypical CBN ( ) but not severely atypical CBN was found compared to melanoma. Similar results were obtained when comparing these classes of CBN with malignant CBN. Compared to conventional nevi, benign/mildly and moderately atypical CBN had similar p16 staining, but a significant decrease in p16 was found in severely atypical CBN ( ). (c) Ki-67 was significantly lower in CBN of all levels of atypia compared to melanoma ( ).

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