Impact of Comorbidity, Race, and Marital Status in Men Referred for Prostate Biopsy with PSA >20 ng/mL: A Pilot Study in High-Risk Patients

Table 3

Association of CCI with positive biopsy and tumor grade.

	Univariate (95% CI)	value	Multivariate (95% CI)	value
Positive biopsy* (OR)	1.13 (0.80, 1.59)	0.50	1.42 (0.75, 2.71)	0.28
Gleason score^† (OR)
Gleason 6	1		1
Gleason 7	2.37 (0.88, 6.37)	0.09	4.06 (1.04, 15.89)	0.04
Gleason 8–10	2.58 (0.97, 6.83)	0.06	4.52 (1.16, 17.54)	0.03

OR: odds ratio, CI: confidence interval, CCI: Charlson Comorbidity Index, PSA: prostate-specific antigen.
*Logistic regression analysis; multivariable analysis adjusted for age, race, log-transformed PSA, and BMI.
^†Multinomial logistic regression analysis; multivariable analysis adjusted for BMI, race, and log-transformed PSA.