Table of Contents
International Scholarly Research Notices
Volume 2014, Article ID 369473, 9 pages
http://dx.doi.org/10.1155/2014/369473
Research Article

Facile Synthesis, Characterization, and In Vitro Antimicrobial and Anticancer Activities of Biscoumarin Copolyester Bearing Pendant 3-(Trifluoromethyl)Styrene

Postgraduate and Research Department of Chemistry, Pachaiyappa’s College, Chennai 600 030, India

Received 20 May 2014; Revised 28 July 2014; Accepted 31 July 2014; Published 28 October 2014

Academic Editor: Qingling Feng

Copyright © 2014 Narendran Kandaswamy and Nanthini Raveendiran. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Synthesis of random biscoumarin copolyester bearing pendant 3-(trifluoromethyl)styrene was prepared by the reaction of biscoumarin monomer 3 and hydroquinone 5 with azeloyl chloride. The influence of pendant 3-(trifluoromethyl)styrene unit on the properties of copolyester such as inherent viscosity, solubility, and thermal stability was investigated and compared in detail. The inherent viscosity and polydispersity index of the copolyester were found to be 0.15 dL/g and 1.36, respectively. The chemical structure of the copolyester was investigated by Fourier-transform infrared spectroscopy (FTIR) and proton nuclear magnetic resonance (1H-NMR) spectroscopy. The physical properties of copolyester were characterized by thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), gel permeation chromatography (GPC), and X-ray diffraction (XRD) technique. Agar disc diffusion method was employed to study the antimicrobial activity of the random copolyester. In vitro anticancer activity against lung cancer (Hep-2) cell line was also investigated.