Research Article
Urinary Biomarkers of Acute Kidney Injury in Patients with Liver Cirrhosis
Table 1
Demographic, clinical, and laboratory data of all patients.
| | | No ascites () | Ascites without impairment of kidney function () | Ascites with impairment of kidney function () | |
| | Age (years) | 53.3 ± 9.6 | 54.04 ± 11.03 | 52.95 ± 9.74 | 0.85 | | Gender, male | 24 (57%) | 30 (60%) | 49 (72%) | 0.21 | | Etiology of cirrhosis HCV/HBV/others | 32/7/3 | 39/8/3 | 54/10/4 | 0.99 | | Hepatic encephalopathy, (%) | 6 (14%) | 19 (38%) | 32 (47%) | 0.004 | | Gastrointestinal bleeding, (%) | 7 (16%) | 13 (26%) | 25 (36%) | 0.173 | | Serum bilirubin (mg/dL) | 2.8 ± 1.76 | 4.4 ± 2.6 | 6.9±4 | 0.0001 | | Serum albumin (g/L) | 31.5 ± 6.1 | 25.58 ± 3.69 | 27.72 ± 5.61 | 0.0001 | | Prothrombin time (%) | 67.14 ± 18.4 | 58.18 ± 8.84 | 47.91 ± 15.92 | 0.0001 | | Serum creatinine (mg/dL) | 0.761 ± 0.19 | 1.045 ± 0.26 | 2.38 ± 0.95 | 0.0001 | | Glomerular filtration rate (mL/min/1.73 m2) | 119.53 ± 33.57 | 85 ± 21.87 | 45.18 ± 21.28 | 0.0001 | | Serum sodium (mEq/L) | 135.26 ± 3.8 | 134.92 ± 4.96 | 131.72 ± 6.46 | 0.001 | | Serum potassium (mEq/L) | 3.979 ± 0.42 | 4 ± 0.54 | 4.39 ± 0.78 | 0.001 | | Child-Pugh score | 7.48 ± 1.86 | 9.86 ± 1.22 | 10 ± 2 | 0.0001 | | MELD score | 13.54 ± 3.06 | 16. ± 4.81 | 25.74 ± 7.76 | 0.0001 | | Mean arterial pressure (mmHg) | 83.76 ± 13.9 | 82.66 ± 15.5 | 77 ± 14.8 | 0.035 | | Urine sodium (mEq/L) | 49.71 ± 34.5 | 47.34 ± 29.34 | 36.6 ± 21.27 | 0.029 | | Urinary IL-18 (µg/g creatinine) | 254.5 ± 77.9 | 296.56 ± 113 | 983.48 ± 594.43 | 0.001 | | Urinary NGAL (µg/g creatinine) | 96.84 ± 35.58 | 113.76 ± 47.98 | 357.78 ± 228.51 | 0.001 |
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MELD: Model for End-Stage Liver Disease and NGAL: neutrophil-gelatinase-associated lipocalin.
Significant at ; ; and .
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