High-Amylose Sodium Carboxymethyl Starch Matrices: Development and Characterization of Tramadol Hydrochloride Sustained-Release Tablets for Oral Administration

Figure 5

Cumulative percentage of tramadol hydrochloride released in vitro from once-daily SD HASCA tablets with 100 mg of drug and once-daily commercial formulations with 100 mg of drug in a pH gradient versus a 40% ethanol hydroalcoholic medium (▲: SD HASCA with 100 mg in a pH gradient, ◆: Tridural 100 mg in a pH gradient, ●: SD HASCA with 100 mg in a 40% ethanolic medium, and ■: Tridural 100 mg in a 40% ethanolic medium). 𝑓₂ values: 70.66 between 700-mg tablets with 100 mg of drug and Tridural 100 mg in pH gradient, 88.51 between 700-mg tablets with 100 mg of drug and Tridural 100 mg in a 40% ethanol hydroalcoholic medium.