Research Article

High-Amylose Sodium Carboxymethyl Starch Matrices: Development and Characterization of Tramadol Hydrochloride Sustained-Release Tablets for Oral Administration

Table 2

Time to release 50% (T50%) and 90% (T90%) of drug from SD HASCA tablets with total weights between 400mg and 800mg and % of drug (w/w) between 12.5% and 60%.

TW (mg)[T50%, T90%] (h)% of drug (w/w)
12.514.32022.22253037.5405060

400T50%1.81.51.41.31.1
T90%6.55.34.54.63.5
450T50%1.9
T90%6.4
500T50%2.552.051.91.751.4
T90%8.757.66.75.94.65
700T50%4
T90%14.4
800T50%4.94.13.32.72.5
T90%18.416.411.510.259.3