High-Amylose Sodium Carboxymethyl Starch Matrices: Development and Characterization of Tramadol Hydrochloride Sustained-Release Tablets for Oral Administration

Table 3

Time to release 50% and 90% of tramadol hydrochloride [T50%, T90%] from twice-daily (every 12 hours) and once-daily (every 24 hours) commercially SR formulations and SD HASCA formulations (produced with the SSP), with 100 mg and 200 mg of drug. Release times are presented in hours.

(a) Frequency of administration: twice-daily

Formulation
Commercial			SD HASCA (SSP)
Topalgic LP; 100 mg	Topalgic LP; 200 mg	Contramal LP; 200 mg	100 mg; of drug (SSP)	200 mg; of drug (SSP)
[2.15, 7.60]	[2.00, 6.90]	[2.10, 6.85]	[3.00, 10.70]	[3.00, 10.25]

(b) Frequency of administration: Once-daily

Formulation
Commercial				SD HASCA (SSP)
Tridural; 100 mg	Tridural; 200 mg	Ralivia; 200 mg	Zytram XL 200 mg	100 mg; of drug (SSP)	200 mg; of drug (SSP)
[6.10, 15.70]	[6.00, 19.50]	[6.40, 11.60]	[7.50, >24]	[5.10, 20.40]	[5.20, 19.10]