Angiotensin Type-1 Receptor Blockade May Not Protect Kidney against Cisplatin-Induced Nephrotoxicity in Rats

Figure 1

Comparison of the measured biochemistry parameters in serum and kidney tissue, kidney damage score, kidney weight, and body weight between the negative (treated with losartan alone) and positive (treated with CP alone) control groups. Data is reported as mean ± SEM. *indicates significant difference from the negative control groups, and ^#indicates significant difference from L20 group (𝑃<0.05). BUN: blood urea nitrogen, Cr: creatinine, SMDA: serum malondialdehyde, Mg: magnesium, Snitrite: serum nitrite, KMDA: kidney MDA, Knitrite: kidney nitrite, KW: kidney weight per 100 g bodyweight, L10 and L20: losartan treated groups with dose of 10 and 20 mg/kg, respectively, and CP: cisplatin.

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