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ISRN Analytical Chemistry
Volume 2014 (2014), Article ID 486842, 8 pages
Research Article

Ginsenosides in Commercial Ginseng Products Analyzed by Liquid Chromatography-Tandem Mass Spectrometry

1Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, Canada V5A 1S6
2Western Region Laboratory, Regions and Programs Branch, British Columbia Region, Health Canada, 3155 Willingdon Green, Burnaby, BC, Canada V5G 4P2

Received 27 November 2013; Accepted 18 December 2013; Published 10 February 2014

Academic Editors: W. Lee and Z. Zhao

Copyright © 2014 Linda Uhr et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Although the LC/MS-MS method has been developed to analyze ginsenosides in ginseng roots, this method has not yet been utilized to quantify ginsenosides in ginseng products. In this paper, an internal standard method by LC/MS-MS was developed to analyze the ginsenosides content in the commercial ginseng products such as the ginseng capsules. We compare the standard addition method and the internal standard methods for the quantification of several ginsenosides (e.g., Rb1, Rb2, Rb3, Rc, Rd, Re, Rg1, and Rg3) in five commercial ginseng capsules. The results showed that the internal standard method is as good as the standard addition method and is a less tedious approach.