Lower Plasma Creatinine and Urine Albumin in Individuals at Increased Risk of Type 2 Diabetes with Factor V Leiden Mutation

Table 1

Participant characteristics of the total cohort and those subjects with available urine samples are displayed.

Characteristic	All subjects		𝑃	Subjects with urine samples		𝑃
	Wildtype	FVL mutation		Wildtype	FVL mutation
𝑁	1780	125	—	744	56	—
Gender (females/males)	1171/609	84/41	0.75*	481/263	41/15	0.19*
Age (years)	39.7±0.3	41.1±1.2	0.26	43.7±0.5	44.4±1.7	0.72
Diabetes	99 (5.6%)	6 (4.8%)	0.71*	57 (7.7%)	3 (5.4%)	0.53*
Body weight (kg)	87.7±0.6	85.7±2.4	0.41	99.3±1.12	95.6±4.10	0.38
BMI (kg·m^−2)	30.17±0.21	29.73±0.81	0.61	34.30±0.37	33.36±1.37	0.50
Lean body mass (kg)	57.02±0.33	55.63±1.27	0.29	60.09±0.60	57.84±2.19	0.32
HbA1c (%)	5.42±0.01	5.42±0.05	0.88	5.69±0.02	5.59±0.09	0.26
Blood pressure syst. (mmHg)	123.9±0.49	126.4±1.84	0.19	125.8±0.6	125.9±2.18	0.94
Blood pressure diast. (mmHg)	77.8±0.33	78.6±1.24	0.55	79.4±0.4	79.5±1.44	0.96
Insulin sensitivityOGTT (AU)	14.94±0.25	14.64±0.95	0.76	11.48±0.34	11.87±1.29	0.77
Fasting glucose (mmol/L)	5.20±0.02	5.26±0.06	0.34	5.39±0.02	5.27±0.09	0.19
Plasma creatinine (mg/dL)	0.849±0.004	0.822±0.014	0.07	0.856±0.006	0.825±0.024	0.24
Urine albumin (mg/L)	—	—	—	31.3±7.6	10.7±27.6	0.03
Plasma creatinine (mg/dL)**	0.849±0.003	0.823±0.013	𝟎.𝟎𝟒𝟖^∗∗	—	—	—

Values represent means ± SE (standard error). For statistical analyses, nonnormally distributed parameters were log transformed. ISI: insulin sensitivity index. Significant differences are marked by bold font.
∗Chi-square test; ∗∗adjusted for age, gender, and lean body mass.