The Neuroepithelium Disruption Could Generate Autoantibodies against AQP4 and Cause Neuromyelitis Optica and Hydrocephalus

Figure 2

Flow chart representing the hypothesis that the cell junction pathology of the VZ cells leads to hydrocephalus, abnormal neurogenesis, and certain types of NMO. Modified from Rodriguez et al. 2012 [16]. NMO = neuromyelitis optica, NMOSD = neuromyelitis optica spectrum disease, NSC = neural stem cells, SVZ = subventricular zone, and VZ = ventricular zone.