Table of Contents
ISRN Pharmacology
Volume 2014, Article ID 608590, 7 pages
Research Article

Efficacy of Composite Extract from Leaves and Fruits of Medicinal Plants Used in Traditional Diabetic Therapy against Oxidative Stress in Alloxan-Induced Diabetic Rats

1Department of Biochemistry & Biochemical Engineering, Sam Higginbottom Institute of Agriculture, Technology and Sciences, Allahabad 211007, India
2Department of Biochemistry, University of Allahabad, Allahabad 211002, India

Received 13 November 2013; Accepted 8 January 2014; Published 4 March 2014

Academic Editors: R. Couture, G. Gervasini, M. Labieniec, and S. Tsuruoka

Copyright © 2014 Brahm Kumar Tiwari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Oxidative stress plays a vital role in diabetic complications. To suppress the oxidative stress mediated damage in diabetic pathophysiology, a special focus has been given on composite extract (CE) and making small dose of naturally occurring antidiabetic plants leaf and fruits. The aim of the present study was to evaluate the beneficial role of CE against alloxan- (ALX-) induced diabetes of Wistar strain rats. A dose-dependent study for CE (25, 50, and 100 mg/kg body weight) was carried out to find the effective dose of the composite compound in ALX-induced diabetic rats. ALX exposure elevated the blood glucose, plasma advanced oxidation product (AOPP), sialic acid demonstrating disturbed antioxidant status.CE at a dose of 100 mg/kg body weight restored/minimised these alterations towards normal values. In conclusion, small dose of CE possesses the capability of ameliorating the oxidative stress in ALX-induced diabetes and thus could be a promising approach in lessening diabetic complications.