Research Article

Efficient Electrochemical N-Alkylation of N-Boc-Protected 4-Aminopyridines: Towards New Biologically Active Compounds

Table 4

Antifungal activity of selected 4APsa.

CompoundCandida albicans (3 strains)Candida parapsilosis ATCC22019Cryptococcus neoformans (2 strains)
MIC50 ( g/mL)MIC100 ( g/mL)MIC50 ( g/mL)MIC100 ( g/mL)MIC50 ( g/mL)MIC100 ( g/mL)

1b>64>64>64>64ndnd
1e>64>64>64>64ndnd
1f>64>64>64>64ndnd
2e>64>6464>64ndnd
2f>64>64>64>64ndnd
3ac11.3b26.9b32320.4cnd
3ae26.9b32bndnd4cnd
3cc>64>64>64>6464>64
3ee>64>64>64>643264
3ff>64>64>64>64832
Fluconazole1nd2nd2nd
Amphotericin Bnd0.79nd1nd0.5

The values are expressed as geometric mean of minimum inhibitory concentration (MIC) determined using Clinical and Laboratory Standard Institute (CLSI) protocol M27-A3. MIC50: lowest drug concentration that prevented 50% of growth with respect to the untreated control control. MIC100: lowest drug concentration that prevented 100% of growth with respect to the untreated control. b8 Candida  albicans strains were tested. c4 Cryptococcus neoformans strains were tested.