Safety Evaluation of Zingiber cassumunar Roxb. Rhizome Extract: Acute and Chronic Toxicity Studies in Rats

Table 2

Absolute organ weights (g) of rats receiving a single dose of Z. cassumunar extract granules for 14 days^a.

Organ	Control	5000 mg/kg bw
Female
Brain	1.85 ± 0.02	1.82 ± 0.03
Lungs	1.10 ± 0.03	1.27 ± 0.05^*
Heart	0.85 ± 0.02	0.81 ± 0.02
Livers	6.61 ± 0.31	7.08 ± 0.30
Spleen	0.72 ± 0.02	0.85 ± 0.06
Pancreas	0.58 ± 0.02	0.55 ± 0.04
Adrenals	0.03 ± 0.00	0.03 ± 0.00
Kidneys	0.78 ± 0.01	0.84 ± 0.02^*
Ovary	0.06 ± 0.00	0.06 ± 0.00
Uterus	0.49 ± 0.03	0.50 ± 0.03
Male
Brain	1.99 ± 0.01	1.95 ± 0.02
Lungs	1.38 ± 0.03	1.32 ± 0.05
Heart	1.10 ± 0.02	1.07 ± 0.03
Livers	10.36 ± 0.21	11.13 ± 0.35
Spleen	1.00 ± 0.03	0.88 ± 0.04^*
Pancreas	0.69 ± 0.03	0.73 ± 0.03
Adrenals	0.03 ± 0.00	0.03 ± 0.00
Kidneys	1.25 ± 0.03	1.18 ± 0.02
Testes	1.72 ± 0.02	1.70 ± 0.01
Epididymis	0.54 ± 0.01	0.49 ± 0.01^*

Values are expressed as mean ± SEM (n = 10 for each group).
values < 0.05, compared to the corresponding control.