Table of Contents
ISRN Nephrology
Volume 2014, Article ID 634515, 7 pages
http://dx.doi.org/10.1155/2014/634515
Clinical Study

Effect of α-Lipoic Acid on Oxidative Stress in End-Stage Renal Disease Patients Receiving Intravenous Iron

1Division of Nephrology, Department of Medicine, University of Tennessee Health Science Center, 956 Court Avenue, Suite B224, Memphis, TN 38163, USA
2Emergency Department, Methodist Affiliated Hospitals, Memphis, TN 38163, USA
3Department of Clinical Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA

Received 13 December 2013; Accepted 29 January 2014; Published 5 March 2014

Academic Editors: A. Arduini, E. Costa, and L. Djukanovic

Copyright © 2014 Arif Showkat et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. S. Levey, J. A. Beto, B. E. Coronado et al., “Controlling the epidemic of cardiovascular disease in chronic renal disease: what do we know? What do we need to learn? Where do we go from here?” The American Journal of Kidney Diseases, vol. 32, no. 5, pp. 853–906, 1998. View at Google Scholar · View at Scopus
  2. M. A. Spittle, N. A. Hoenich, G. J. Handelman, R. Adhikarla, P. Homel, and N. W. Levin, “Oxidative stress and inflammation in hemodialysis patients,” The American Journal of Kidney Diseases, vol. 38, no. 6, pp. 1408–1413, 2001. View at Google Scholar · View at Scopus
  3. R. Agarwal, N. Vasavada, N. G. Sachs, and S. Chase, “Oxidative stress and renal injury with intravenous iron-in patients with chronic kidney disease,” Kidney International, vol. 65, no. 6, pp. 2279–2289, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. P. S. Lim, Y. H. Wei, Y. L. Yu, and B. Kho, “Enhanced oxidative stress in haemodialysis patients receiving intravenous iron therapy,” Nephrology Dialysis Transplantation, vol. 14, no. 11, pp. 2680–2687, 1999. View at Google Scholar · View at Scopus
  5. J. M. Roob, G. Khoschsorur, A. Tiran, J. H. Horina, H. Holzer, and B. M. Winklhofer-Roob, “Vitamin E attenuates oxidative stress induced by intravenous iron in patients on hemodialysis,” Journal of the American Society of Nephrology, vol. 11, no. 3, pp. 539–549, 2000. View at Google Scholar · View at Scopus
  6. D. J. Leehey, D. J. Palubiak, S. Chebrolu, and R. Agarwal, “Sodium ferric gluconate causes oxidative stress but not acute renal injury in patients with chronic kidney disease: a pilot study,” Nephrology Dialysis Transplantation, vol. 20, no. 1, pp. 135–140, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. D. del Rio, A. J. Stewart, and N. Pellegrini, “A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress,” Nutrition, Metabolism and Cardiovascular Diseases, vol. 15, no. 4, pp. 316–328, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. A. W. Girotti, “Lipid hydroperoxide generation, turnover, and effector action in biological systems,” Journal of Lipid Research, vol. 39, no. 8, pp. 1529–1542, 1998. View at Google Scholar · View at Scopus
  9. P. Montuschi, P. J. Barnes, and L. J. Roberts II, “Isoprostanes: markers and mediators of oxidative stress,” The FASEB Journal, vol. 18, no. 15, pp. 1791–1800, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. K. N. Islam, D. O'Byrne, S. Devaraj, B. Palmer, S. M. Grundy, and I. Jialal, “Alpha-tocopherol supplementation decreases the oxidative susceptibility of LDL in renal failure patients on dialysis therapy,” Atherosclerosis, vol. 150, no. 1, pp. 217–224, 2000. View at Google Scholar · View at Scopus
  11. E. M. de Cavanagh, L. Ferder, F. Carrasquedo et al., “Higher levels of antioxidant defenses in enalapril-treated versus non- enalapril-treated hemodialysis patients,” The American Journal of Kidney Diseases, vol. 34, no. 3, pp. 445–455, 1999. View at Google Scholar · View at Scopus
  12. O. Ziouzenkova, L. Asatryan, C. Tetta, M. L. Wratten, J. Hwang, and A. Sevanian, “Oxidative stress during ex vivo hemodialysis of blood is decreased by a novel hemolipodialysis procedure utilizing antioxidants,” Free Radical Biology and Medicine, vol. 33, no. 2, pp. 248–258, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. G. Clermont, S. Lecour, J. F. Cabanne et al., “Vitamin E-coated dialyzer reduces oxidative stress in hemodialysis patients,” Free Radical Biology and Medicine, vol. 31, no. 2, pp. 233–241, 2001. View at Publisher · View at Google Scholar · View at Scopus
  14. D. Ziegler, H. Nowak, P. Kempler, P. Vargha, and P. A. Low, “Treatment of symptomatic diabetic polyneuropathy with the antioxidant α-lipoic acid: a meta-analysis,” Diabetic Medicine, vol. 21, no. 2, pp. 114–121, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. K. Marangon, S. Devaraj, O. Tirosh, L. Packer, and I. Jialal, “Comparison of the effect of α-lipoic acid and α-tocopherol supplementation on measures of oxidative stress,” Free Radical Biology and Medicine, vol. 27, no. 9-10, pp. 1114–1121, 1999. View at Publisher · View at Google Scholar · View at Scopus
  16. J. R. Hahm, B. J. Kim, and K. W. Kim, “Clinical experience with thioctacid (thioctic acid) in the treatment of distal symmetric polyneuropathy in Korean diabetic patients,” Journal of Diabetes and Its Complications, vol. 18, no. 2, pp. 79–85, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Teichert, R. Hermann, P. Ruus, and R. Preiss, “Plasma kinetics, metabolism, and urinary excretion of alpha-lipoic acid following oral administration in healthy volunteers,” Journal of Clinical Pharmacology, vol. 43, no. 11, pp. 1257–1267, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Teichert, T. Tuemmers, H. Achenbach et al., “Pharmacokinetics of alpha-lipoic acid in subjects with severe kidney damage and end-stage renal disease,” Journal of Clinical Pharmacology, vol. 45, no. 3, pp. 313–328, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. F. B. Stentz and A. E. Kitabchi, “Palmitic acid-induced activation of human T-lymphocytes and aortic endothelial cells with production of insulin receptors, reactive oxygen species, cytokines, and lipid peroxidation,” Biochemical and Biophysical Research Communications, vol. 346, no. 3, pp. 721–726, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. F. B. Stentz, G. E. Umpierrez, R. Cuervo, and A. E. Kitabchi, “Proinflammatory cytokines, markers of cardiovascular risks, oxidative stress, and lipid peroxidation in patients with hyperglycemic crises,” Diabetes, vol. 53, no. 8, pp. 2079–2086, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. R. L. Pisoni, D. S. Fuller, B. A. Bieber, B. W. Gillespie, and B. M. Robinson, “The DOPPS practice monitor for US dialysis care: trends through August 2011,” The American Journal of Kidney Diseases, vol. 60, no. 1, pp. 160–165, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. A. B. Pai, A. V. Boyd, C. R. McQuade, A. Harford, J. P. Norenberg, and P. G. Zager, “Comparison of oxidative stress markers after intravenous administration of iron dextran, sodium ferric gluconate, and iron sucrose in patients undergoing hemodialysis,” Pharmacotherapy, vol. 27, no. 3, pp. 343–350, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. J. M. McCord, “Iron, free radicals, and oxidative injury,” Seminars in Hematology, vol. 35, no. 1, pp. 5–12, 1998. View at Google Scholar · View at Scopus
  24. H. Moini, L. Packer, and N. E. Saris, “Antioxidant and prooxidant activities of α-lipoic acid and dihydrolipoic acid,” Toxicology and Applied Pharmacology, vol. 182, no. 1, pp. 84–90, 2002. View at Publisher · View at Google Scholar · View at Scopus
  25. F. Bhatti, R. W. Mankhey, L. Asico, M. T. Quinn, W. J. Welch, and C. Maric, “Mechanisms of antioxidant and pro-oxidant effects of α-lipoic acid in the diabetic and nondiabetic kidney,” Kidney International, vol. 67, no. 4, pp. 1371–1380, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. L. Packer, E. H. Witt, and H. J. Tritschler, “Alpha-lipoic acid as a biological antioxidant,” Free Radical Biology and Medicine, vol. 19, no. 2, pp. 227–250, 1995. View at Publisher · View at Google Scholar · View at Scopus
  27. B. C. Scott, O. I. Aruoma, P. J. Evansi et al., “Lipoic and dihydrolipoic acids as antioxidants. A critical evaluation,” Free Radical Research, vol. 20, no. 2, pp. 119–133, 1994. View at Google Scholar · View at Scopus
  28. Y. J. Suzuki, M. Tsuchiya, and L. Packer, “Antioxidant activities of dihydrolipoic acid and its structural homologues,” Free Radical Research Communications, vol. 18, no. 2, pp. 115–122, 1993. View at Google Scholar · View at Scopus
  29. A. Childs, C. Jacobs, T. Kaminski, B. Halliwell, and C. Leeuwenburgh, “Supplementation with vitamin C and N-acetyl-cysteine increases oxidative stress in humans after an acute muscle injury induced by eccentric exercise,” Free Radical Biology and Medicine, vol. 31, no. 6, pp. 745–753, 2001. View at Publisher · View at Google Scholar · View at Scopus