| | Protein | Number of TMs | Other structural features | Function | Experimentally validated targets | Tissues/cells/compartments it is highly expressed in | Regulated by | Key references |
| | MARCH1 | 2 | Tyrosine based intracellular sorting motif; tyrosine based endosomal sorting motif (YXXΦ); di-leucine based endosomal sorting motif C-terminal PDZ-binding domain | Regulator of antigen presentation; regulator of lymphocyte development | CD95 (Fas), TfR, HLA-DR, -DM, -DO; B7.2, CD98 | Immature DCs, B cells, monocytes | IL-10, CD83, Tollip | [6, 43, 44, 46–50, 55–57] |
| | MARCH2 | 2 | Tyrosine based motif (YXXΦ); C-terminal PDZ-binding domain | Regulator of cell polarity; regulator of GCPRs signaling; modulator of intracellular trafficking of proteins | TfR, B7.2, BLG1, β2-adrenergic receptor, SX6, CAL | Heart | — | [31, 36, 63, 64, 66] |
| | MARCH3 | 2 | Tyrosine based motif (YXXΦ); C-terminal PDZ-binding domain | Modulator of intracellular trafficking of proteins | Bap31, SX6 | Lung, colon, spleen | — | [31, 35, 37, 65] |
| | MARCH4 | 2 | Tyrosine based motif (YXXΦ); C-terminal PDZ-binding domain | Modulator of NK cell targeting; regulator of the development of the immune system | Bap31, MHC I, HLA-2.1, CD4, ALCAM, Mult1, SX4, CD81, B7.2 | Brain, placenta, lungs, pancreas, some Golgi compartments | — | [15, 31, 37, 67] |
| MARCH5
(MITOL) | 4 | — | Regulator of mitochondrial morphology; regulator of neuronal cell death when under stress; positive regulator of TLR7 signaling; protects cells from cytotoxicity | MFN1, MFN2, Drp1, hFis1, TANK, mSOD1, ΔNAT-3Q71, S-nitrosylated LC1 | Mitochondrial outer membrane, bronchial epithelial cells, thyroid, B cells | — | [38, 39, 70–77] |
| MARCH6
(TEB4) | 14 | TEB-Doa (TD) domain | Involved in recognition of specific targets for ERAD; associated with Cri-du-chat syndrome; regulator of response to cold temperatures; regulator of cholesterol production | D2, SM | ER membrane, nuclear envelope; most tissues | — | [40, 41, 80, 81] |
| MARCH7
(Axot) | 0 | N-terminus has serine/proline rich region; Tyrosine based motif (YXXΦ); RING-CH domain close to the C-terminus; non-classical importin-α nuclear localization signal (SKRPKL) | Confers stem cell properties; role in neuronal development; regulates immune tolerance | — | Mouse embryonic, neural and hematopoietic stem cells, human epithelial cells, human trophoblasts; rat testis; nucleus | — | [83, 85–88] |
| MARCH8
(c-MIR) | 2 | Tyrosine based motif (YXXΦ); C-terminal PDZ-binding domain | Regulator of the inflammatory response; regulator of CD4+ T cell development; regulator of apoptosis; possible restriction factor; Involved in zebrafish and Xenopus laevis embryogenesis | MHC I HLA-2.1, MHC II, CD95 (Fas), B7.2, TfR, CD166, CD44, CD88, CD98, IL1RAP, TRAIL-R1, SX4, CD166, Bap31, E-cadherin | Lung; developing zebrafish embryo; developing Xenopus laevis embryo; early endosomes, late endosomes, cell surface | — | [6, 15, 30, 31, 37, 46, 95, 96, 99–103] |
| | MARCH9 | 2 | C-terminal PDZ-binding domain; splice variant that does not contain a RING-CH domain | Regulator of the immune response; modulator of NK cell targeting | MHC I, HLA-DM, -DQ, -DR, -DO, CD4, ALCAM, ICAM-1, FcγRIIB, SLAM, PTPRJ, ILT-2, Mult1 | Human placenta; mouse brain; mouse kidneys; B cells, T cells, DCs; trans-Golgi network | — | [31, 37, 67, 104, 106] |
| | MARCH10 | 0 | RING-CH domain close to the C-terminus; Exists as two isoforms due to alternative splicing | Regulator of spermatogenesis | — | Human testicular germ cells; developing rat spermatids | — | [68, 108] |
| | MARCH11 | 2 | Tyrosine based motif (YXXΦ); RING-CH domain close to the C-terminus; N-terminal proline rich region | Involved in rat spermatogenesis; involved in the ubiquitin-dependent protein-sorting pathway | CD4, SAMT1 | Rat testis; TGN, MVBs | — | [32, 109] |
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