International Scholarly Research Notices / 2014 / Article / Tab 2

Research Article

Synthesis and Biological Activities of 4-Aminoantipyrine Derivatives Derived from Betti-Type Reaction

Table 2

Results of anthelmintic activity of 4-aminoantipyrine derivatives 4(a–h).

Test Compds12.5 mg/mL25 mg/mL50 mg/mL100 mg/mL150 mg/mL
Time of paralysis (min.)Time of death
(min.)
Time of paralysis
(min.)
Time of death
(min.)
Time of paralysis
(min.)
Time of death
(min.)
Time of paralysis
(min.)
Time of death
(min.)
Time of paralysis
(min.)
Time of death
(min.)

Control
ALB21 ± 0.622 ± 0.518 ± 0.4*19 ± 0.615 ± 1.017 ± 0.813 ± 1.214 ± 0.6*10 ± 0.510 ± 1.8*
4a22 ± 1.423 ± 0.519 ± 1.520 ± 0.7*16 ± 1.017 ± 0.614 ± 0.7*15 ± 1.3*11 ± 0.511 ± 1.0*
4b23 ± 1.523 ± 1.3*20 ± 2.1*21 ± 2.318 ± 1.220 ± 1.015 ± 1.2*16 ± 1.712 ± 0.512 ± 0.3
4c30 ± 0.631 ± 0.5*28 ± 1.329 ± 1.0*26 ± 0.7*27 ± 0.922 ± 0.523 ± 0.720 ± 1.2*19 ± 0.7
4d39 ± 0.942 ± 1.537 ± 1.440 ± 1.235 ± 1.335 ± 1.233 ± 0.634 ± 0.731 ± 0.832 ± 0.4
4e24 ± 0.8*24 ± 1.321 ± 1.322 ± 0.1*17 ± 0.617 ± 1.6*14 ± 0.715 ± 1.012 ± 0.8*12 ± 0.2
4f30 ± 1.0*30 ± 0.629 ± 0.330 ± 1.027 ± 1.228 ± 0.6*24 ± 0.525 ± 1.220 ± 1.521 ±1.2
4g21 ± 0.423 ± 0.719 ± 0.319 ± 1.116 ± 1.017 ± 0.613 ± 1.714 ± 0.6*12 ± 1.012 ± 1.2
4h29 ± 0.330 ± 0.526 ± 1.327 ± 1.024 ± 0.2*24 ± 0.6*21 ± 0.722 ± 0.418 ± 1.019 ± 1.2*

Standard drug, Albendazole (ALB), was used at 10 mg/mL; “—” indicates absence of activity in 24 h of administration. *Significantly different from ALB at .