Adding of Sitagliptin on Insulin Therapy Effectively and Safely Reduces a Hemoglobin A1c Level and Glucose Fluctuation in Japanese Patients with Type 2 Diabetes

Table 3

Relationship between ΔHbA1c and each nominal variable.

Predictive variable	𝑛	ΔHbA1c (%)	𝑃 value
Gender
Male	124	−0.67±1.28	N.S.
Female	92	−0.66±0.90
Combined with other OHAs
None	98	−0.67±0.98	N.S.
+	118	−0.66±1.25
Combined with SU
None	194	−0.68±1.16	N.S.
+	22	−0.51±0.81
Combined with BG
None	123	−0.65±1.08	N.S.
+	93	−0.69±1.20
Combined with 𝛼-GI
None	194	−0.72±1.10	0.033
+	22	−0.10±1.25
Insulin therapy
Premixed	95	−0.96±1.31	0.002
MDI	74	−0.48±0.98
Basal insulin	47	−0.35±0.78

Abbreviations are shown in text. Student’s 𝑡-test or one-way ANOVA.
Δ = (value after 3 months) − (value before add-on of sitagliptin).
Premixed: twice or thrice daily injections of premixed insulin. MDI: multiple daily injections composed of long acting insulin once or twice and rapid acting insulin at each meal time. N.S.: not significant.