Table of Contents
International Scholarly Research Notices
Volume 2014 (2014), Article ID 652713, 6 pages
http://dx.doi.org/10.1155/2014/652713
Research Article

Concentrated Hypoxia-Preconditioned Adipose Mesenchymal Stem Cell-Conditioned Medium Improves Wounds Healing in Full-Thickness Skin Defect Model

1Department of Human Sports Science, Nanjing Institute of Physical Education, Nanjing 210014, China
2Nanjing Regenerative Medicine Engineering and Technology Research Center, Nanjing 210046, China

Received 15 August 2014; Revised 25 October 2014; Accepted 4 November 2014; Published 26 November 2014

Academic Editor: Hiroshi Mizuno

Copyright © 2014 Biao Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. E. Godwin, N. J. Young, J. Dudhia, I. C. Beamish, and R. K. W. Smith, “Implantation of bone marrow-derived mesenchymal stem cells demonstrates improved outcome in horses with overstrain injury of the superficial digital flexor tendon,” Equine Veterinary Journal, vol. 44, no. 1, pp. 25–32, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Modo, P. Rezaie, P. Heuschling, S. Patel, D. K. Male, and H. Hodges, “Transplantation of neural stem cells in a rat model of stroke: assessment of short-term graft survival and acute host immunological response,” Brain Research, vol. 958, no. 1, pp. 70–82, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. A. J. B. O. G. Salgado, R. L. G. Reis, N. J. C. Sousa, and J. M. Gimble, “Adipose tissue derived stem cells secretome: soluble factors and their roles in regenerative medicine,” Current Stem Cell Research and Therapy, vol. 5, no. 2, pp. 103–110, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. T. L. Yew, Y. T. Hung, H. Y. Li et al., “Enhancement of wound healing by human multipotent stromal cell conditioned medium: the paracrine factors and p38 MAPK activation,” Cell Transplantation, vol. 20, no. 5, pp. 693–706, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. L. Chen, Y. Xu, J. Zhao et al., “Conditioned medium from hypoxic bone marrow-derived mesenchymal stem cells enhances wound healing in mice,” PLoS ONE, vol. 9, no. 4, Article ID e96161, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. P. A. Zuk, M. Zhu, P. Ashjian et al., “Human adipose tissue is a source of multipotent stem cells,” Molecular Biology of the Cell, vol. 13, no. 12, pp. 4279–4295, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Sato, M. Sato, H. Kanai et al., “Mitochondrial reactive oxygen species and c-Src play a critical role in hypoxic response in vascular smooth muscle cells,” Cardiovascular Research, vol. 67, no. 4, pp. 714–722, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. B. Xiong, J.-H. Gao, H.-D. Chen et al., “Establishment of a rat model of bone marrow mesenchymal stem cell transplantation for repairing full-thickness skin defect,” Nan Fang Yi Ke Da XueXueBao, vol. 29, no. 5, pp. 898–905, 2009. View at Google Scholar · View at Scopus
  9. P. A. Zuk, M. Zhu, H. Mizuno et al., “Multilineage cells from human adipose tissue: implications for cell-based therapies,” Tissue Engineering, vol. 7, no. 2, pp. 211–228, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. M. H. Moon, S. Y. Kim, Y. J. Kim, and et al, “Human adipose tissue-derived mesenchymal stem cells improve postnatal neovascularization in a mouse model of hindlimb ischemia,” Cellular Physiology and Biochemistry, vol. 17, no. 5-6, pp. 279–290, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. C.-Y. Fong, K. Tam, S. Cheyyatraivendran et al., “Human Wharton's jelly stem cells and its conditioned medium enhance healing of excisional and diabetic wounds,” Journal of Cellular Biochemistry, vol. 115, no. 2, pp. 290–302, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. L. Chen, E. E. Tredget, P. Y. G. Wu, Y. Wu, and Y. Wu, “Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing,” PLoS ONE, vol. 3, no. 4, Article ID e1886, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. E. Festa, J. Fretz, R. Berry et al., “Adipocyte lineage cells contribute to the skin stem cell niche to drive hair cycling,” Cell, vol. 146, no. 5, pp. 761–771, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. B. S. Park, W. S. Kim, J. S. Choi et al., “Hair growth stimulated by conditioned medium of adipose-derived stem cells is enhanced by hypoxia: Evidence of increased growth factor secretion,” Biomedical Research, vol. 31, no. 1, pp. 27–34, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Pasarica, O. R. Sereda, L. M. Redman et al., “Reduced adipose tissue oxygenation in human obesity evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response,” Diabetes, vol. 58, no. 3, pp. 718–725, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. Q. Lin, Y. Kim, R. M. Alarcon, and Z. Yun, “Oxygen and cell fate decisions,” Gene Regulation and Systems Biology, vol. 2, pp. 43–51, 2008. View at Google Scholar · View at Scopus
  17. H.-M. Chung, C.-H. Won, and J.-H. Sung, “Responses of adipose-derived stem cells during hypoxia: enhanced skin-regenerative potential,” Expert Opinion on Biological Therapy, vol. 9, no. 12, pp. 1499–1508, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Chen, M. Przyborowski, and F. Berthiaume, “Stem cells for skin tissue engineering and wound healing,” Critical Reviews in Biomedical Engineering, vol. 37, no. 4-5, pp. 399–421, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. S. H. Lee, S. Y. Jin, J. S. Song, K. K. Seo, and K. H. Cho, “Paracrine effects of adipose-derived stem cells on keratinocytes and dermal fibroblasts,” Annals of Dermatology, vol. 24, no. 2, pp. 136–143, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. H. B. Park, J. H. Yang, and K. H. Chung, “Characterization of the cytokine profile of platelet rich plasma (PRP) and PRP-induced cell proliferation and migration: upregulation of matrix metalloproteinase-1 and -9 in HaCaT cells,” Korean Journal of Hematology, vol. 46, no. 4, pp. 265–273, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. J. W. Penn, A. O. Grobbelaar, and K. J. Rolfe, “The role of the TGF-beta family in wound healing, burns and scarring: a review,” International Journal of Burns and Trauma, vol. 2, no. 1, pp. 18–28, 2012. View at Google Scholar