Review Article
Laser-Assisted Subepithelial Keratectomy versus Laser In Situ Keratomileusis in Myopia: A Systematic Review and Meta-Analysis
Table 3
Postoperative course and complications of LASIK versus LASEK in the meta-analysis.
| | Number of studies | Crude rate, n/N (%) | Rate difference % (95% CI) | P for overall effect | LASEK | LASIK |
| Low to moderate | | | | | | After 6 months | | | | | | Refractive SE 0.5 D |
1 [5] | 98/122 | 87/122 | 1.64 (0.91, 2.98) | 0.10 | UCVA 20/20 | NA | — | — | — | — | Loss of 1 line of BCVA | 2 [2, 5] | 7/154 | 11/154 | 0.61 (0.23, 1.64) | 0.33 | Corneal haze | 1 [2] | 0/32 | 0/32 | Not estimated | Not estimated | After 12 months | | | | | | Refractive SE ≤ 0.5 D | 2 [3, 7] | 77/80 | 91/95 | 1.38 (0.28, 6.80) | 0.69 | UCVA 20/20 | 1 [7] | 23/30 | 20/30 | 1.64 (0.53, 5.12) | 0.39 | Loss of ≥1 line of BCVA | 2 [3, 7] | 5/95 | 5/95 | 1.00 (0.26, 3.89) | 1.00 | Corneal haze | NA | — | — | — | — | Moderate to high | | | | | | After 6 months | | | | | | Refractive SE ≤ 0.5 D | 1 [12] | 101/146 | 227/324 | 0.96 (0.63, 1.47) | 0.85 | UCVA 20/20 | 1 [12] | 92/146 | 224/324 | 0.76 (0.50, 1.15) | 0.19 | Loss of 1 line of BCVA | 1 [12] | 16/146 | 8/324 | 4.86 (2.03, 11.64) | 0.0004 | Corneal haze | 2 [9, 12] | 37/294 | 2/411 | 54.65 (12.96–230.52) | <0.00001 | After 12 months | | | | | | Refractive SE ≤ 0.5 D | 1 [12] | 101/146 | 227/324 | 0.96 (0.63, 1.47) | 0.85 | UCVA 20/20 | 1 [12] | 88/146 | 232/324 | 0.60 (0.40, 0.91) | 0.02 | Loss of 1 line of BCVA | 1 [12] | 25/146 | 4/324 | 16.53 (5.64, 48.48) | <0.00001 | Corneal haze | 1 [12] | 37/146 | 2/324 | 54.65 (12.96–230.52) | <0.00001 | Flap complications | 3 [1, 8, 12] | 4/443 | 0/265 | 0.24 (0.01–4.54) | 0.34 |
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LASIK: laser in situ keratomileusis, LASEK: laser-assisted subepithelial keratectomy, D: diopter, SE: spherical equivalent, UCVA: uncorrected visual acuity, BCVA: best-corrected visual acuity, and NA: not available.
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