Table of Contents
ISRN Inflammation
Volume 2014, Article ID 701765, 5 pages
http://dx.doi.org/10.1155/2014/701765
Research Article

Scientific Validation of Gentiana kurroo Royle for Anti-Inflammatory and Immunomodulatory Potential

1Department of Biochemistry, University of Kashmir, Srinagar 190 006, India
2Regional Research Institute of Unani Medicine, Kashmir University Campus, Srinagar 190 006, India
3Centre for Biodiversity and Taxonomy (CBT), Department of Botany, University of Kashmir, Srinagar 190 006, India

Received 24 November 2013; Accepted 18 January 2014; Published 23 February 2014

Academic Editors: A. Kamal and J. Meseguer

Copyright © 2014 Khan Mubashir et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. Srinivasan, S. Muruganandan, J. Lal, S. Chandra, S. K. Tandan, and V. Ravi Prakash, “Evaluation of anti-inflammatory activity of Pongamia pinnata leaves in rats,” Journal of Ethnopharmacology, vol. 78, no. 2-3, pp. 151–157, 2001. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Bettini and D. A. Vignali, “Regulatory T cells and inhibitory cytokines in autoimmunity,” Current Opinion in Immunology, vol. 21, no. 6, pp. 612–618, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. R. C. Dutta, “Peptide immunomodulators versus infection; an analysis,” Immunology Letters, vol. 83, no. 3, pp. 153–161, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Perretti and F. D'Acquisto, “Annexin A1 and glucocorticoids as effectors of the resolution of inflammation,” Nature Reviews Immunology, vol. 9, no. 1, pp. 62–70, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. K. De Bosscher, K. Van Craenenbroeck, O. C. Meijer, and G. Haegeman, “Selective transrepression versus transactivation mechanisms by glucocorticoid receptor modulators in stress and immune systems,” European Journal of Pharmacology, vol. 583, no. 2-3, pp. 290–302, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. E. M. Souza-Fagundes, G. Gazzinelli, G. G. Parreira et al., “In vitro activity of labdane diterpene from Alomia myriadenia (Asteraceae): immunosuppression via induction of apoptosis in monocytes,” International Immunopharmacology, vol. 3, no. 3, pp. 383–392, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Mirshafiey, M. R. Khorramizadeh, F. Saadat, and B. H. A. Rehm, “Chemopreventive effect of M2000, a new anti-inflammatory agent,” Medical Science Monitor, vol. 10, no. 10, pp. PI105–PI109, 2004. View at Google Scholar · View at Scopus
  8. K. R. Kirtikar and B. D. Basu, Indian Medicinal Plants, Bishen Singh Mahendra Pal Singh, Dehradun, India, 1935.
  9. B. A. Wani, D. Ramamoorthy, and B. A. Ganai, “Preliminary phytochemical screening and evaluation of analgesic activity of methanolic extract of roots of Gentiana Kurroo Royle in experimental animal models,” International Journal of Pharmacy and Pharmaceutical Sciences, vol. 3, no. 4, pp. 164–166, 2011. View at Google Scholar · View at Scopus
  10. A. Latif, T. F. Khan, and S. H. Afaq, “Anti-inflammatory activity of flower tops of Gentiana kurroo Royale extract,” Pharmacologyonloine, vol. 3, pp. 575–580, 2006. View at Google Scholar
  11. C. A. Winter, E. A. Risley, and G. W. Nuss, “Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs,” Proceedings of the Society for Experimental Biology and Medicine, vol. 111, pp. 544–547, 1962. View at Google Scholar · View at Scopus
  12. D. P. Bhagwat, M. D. Kharya, S. Bani et al., “Immunosuppressive properties of Pluchea lanceolata leaves,” Indian Journal of Pharmacology, vol. 42, no. 1, pp. 21–26, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Thakur, P. Connellan, M. A. Deseo, C. Morris, and V. K. Dixit, “Immunomodulatory polysaccharide from Chlorophytum borivilianum roots,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 598521, 7 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. K. Mangathayaru, M. Umadevi, and C. U. Reddy, “Evaluation of the immunomodulatory and DNA protective activities of the shoots of Cynodon dactylon,” Journal of Ethnopharmacology, vol. 123, no. 1, pp. 181–184, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. M. G. Jayathirtha and S. H. Mishra, “Preliminary immunomodulatory activities of methanol extracts of Eclipta alba and Centella asiatica,” Phytomedicine, vol. 11, no. 4, pp. 361–365, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Lunardelli, C. E. Leite, M. Guerra Simões Pires, and J. Rodrigues De Oliveira, “Extract of the bristles of Dirphia sp. increases nitric oxide in a rat pleurisy model,” Inflammation Research, vol. 55, no. 4, pp. 129–135, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. C.-T. Lin, C.-J. Chen, T.-Y. Lin, J. C. Tung, and S.-Y. Wang, “Anti-inflammation activity of fruit essential oil from Cinnamomum insularimontanum Hayata,” Bioresource Technology, vol. 99, no. 18, pp. 8783–8787, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. Y.-T. Tung, M.-T. Chua, S.-Y. Wang, and S.-T. Chang, “Anti-inflammation activities of essential oil and its constituents from indigenous cinnamon (Cinnamomum osmophloeum) twigs,” Bioresource Technology, vol. 99, no. 9, pp. 3908–3913, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. Yin, F.-Y. Gong, X.-X. Wu et al., “Anti-inflammatory and immunosuppressive effect of flavones isolated from Artemisia vestita,” Journal of Ethnopharmacology, vol. 120, no. 1, pp. 1–6, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. A. F. Suffredini, G. Fantuzzi, R. Badolato, J. J. Oppenheim, and N. P. O'Grady, “New insights into the biology of the acute phase response,” Journal of Clinical Immunology, vol. 19, no. 4, pp. 203–214, 1999. View at Publisher · View at Google Scholar · View at Scopus
  21. G. R. . Romeo, J. Lee, and S. E. Shoelson, “Metabolic syndrome, insulin resistance and roles of inflammation: mechanisms and therapeutic targets,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 32, pp. 1771–1776, 2012. View at Google Scholar