Table of Contents
ISRN Genetics
Volume 2014, Article ID 706516, 6 pages
http://dx.doi.org/10.1155/2014/706516
Research Article

Association of IL10-1082 and IFN-γ+874 Polymorphisms with Cervical Cancer among Tunisian Women

1Laboratory of Micro-Organisms and Active Biomolecules, Faculty of Sciences of Tunis, El Manar University, 2092 El Manar I, 1092 Tunis, Tunisia
2Laboratory of Immunology, Military Hospital of Tunis, 1008 Tunis, Tunisia
3Salah Azeiz Oncology Institute, 1006 Tunis, Tunisia

Received 21 November 2013; Accepted 18 December 2013; Published 6 February 2014

Academic Editors: S. Boisson-Dupuis and P. A. Slominsky

Copyright © 2014 Sabrina Zidi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. The aim of this study was to investigate the role of IL10-1082 and IFN-γ+874 polymorphisms in susceptibility to cervical cancer among Tunisian women. Study Design. The IL10-1082 and IFN-γ+874 polymorphisms were analyzed by ARMS-PCR in 160 healthy women and 122 with cervical cancer. The search for associations between those polymorphisms and cervical cancer was based on the test or Fisher's exact test. Results. The IFN-γ+874 polymorphism showed significant increased frequency of T allele in healthy controls compared with patients (OR = 0.71, 95% CI = 0.50–1.01, and ) and individuals with homozygote IFN-γ+874 T/T genotype were at lesser risk of cervical cancer (OR = 0.53, 95% CI = 0.31–0.92, and ). However, carriers of allele have higher risk for developing cervical cancer (OR = 1.88, 95% CI = 1.09–3.24, and ). At the polymorphic nucleotide in position 1082 of the IL10 promoter, no differences were found between patients and controls subjects. Conclusion. Our study shows that the T/T genotype polymorphism of IFN-γ+874 T>A is a protective factor for cervical cancer among Tunisian women.