Table of Contents
ISRN Genetics
Volume 2014, Article ID 706516, 6 pages
http://dx.doi.org/10.1155/2014/706516
Research Article

Association of IL10-1082 and IFN-γ+874 Polymorphisms with Cervical Cancer among Tunisian Women

1Laboratory of Micro-Organisms and Active Biomolecules, Faculty of Sciences of Tunis, El Manar University, 2092 El Manar I, 1092 Tunis, Tunisia
2Laboratory of Immunology, Military Hospital of Tunis, 1008 Tunis, Tunisia
3Salah Azeiz Oncology Institute, 1006 Tunis, Tunisia

Received 21 November 2013; Accepted 18 December 2013; Published 6 February 2014

Academic Editors: S. Boisson-Dupuis and P. A. Slominsky

Copyright © 2014 Sabrina Zidi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Jemal, F. Bray, M. M. Center, J. Ferlay, E. Ward, and D. Forman, “Global cancer statistics,” CA: Cancer Journal for Clinicians, vol. 61, no. 2, pp. 69–90, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. F. X. Bosch, A. Lorincz, N. Muñoz, C. J. L. M. Meijer, and K. V. Shah, “The causal relation between human papillomavirus and cervical cancer,” Journal of Clinical Pathology, vol. 55, no. 4, pp. 244–265, 2002. View at Google Scholar · View at Scopus
  3. J. Cuzicka, M. Arbynb, R. Sankaranarayananc, V. Tsud, and G. Roncoe, “Overview of human papillomavirus-based and other novel options for cervical cancer screening in developed and developing countries,” Vaccine, vol. 26S, supplement 10, pp. K29–K41, 2008. View at Publisher · View at Google Scholar
  4. A. Hildesheim and S. S. Wang, “Host and viral genetics and risk of cervical cancer: a review,” Virus Research, vol. 89, no. 2, pp. 229–240, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Pawlik, M. Baskiewicz-Masiuk, B. Machalinski, and B. Gawronska-Szklarz, “Association of cytokine gene polymorphisms and the release of cytokines from peripheral blood mononuclear cells treated with methotrexate and dexamethasone,” International Immunopharmacology, vol. 6, no. 3, pp. 351–357, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. M. C. Warlé, A. Furbun, H. J. Metseluur, W. C. J. Hop, C. Perrty, and P. E. Zondervun, “Are cytokine gene polymorphisms related to in vitro cytokine production profiles?” Liver Transplantation, vol. 9, no. 2, pp. 170–181, 2003. View at Google Scholar
  7. J. Bidwell, L. Keen, G. Gallagher et al., “Cytokine gene polymorphism in human disease: on-line databases, Supplement 1,” Genes and Immunity, vol. 2, no. 2, pp. 61–70, 2001. View at Google Scholar · View at Scopus
  8. M.-S. Wu, S.-P. Huang, Y.-T. Chang et al., “Tumor necrosis factor-α and interleukin-10 promoter polymorphisms in Epstein-Barr virus-associated gastric carcinoma,” Journal of Infectious Diseases, vol. 185, no. 1, pp. 106–109, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. N. Shibata, T. Ohnuma, T. Takahashi et al., “Effect of IL-6 polymorphism on risk of Alzheimer disease: genotype-phenotype association study in Japanese cases,” American Journal of Medical Genetics, vol. 114, no. 4, pp. 436–439, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. B. Mugnier, N. Balandraud, A. Darque, C. Roudier, J. Roudier, and D. Reviron, “Polymorphism at position -308 of the tumor necrosis factor α gene influences outcome of infliximab therapy in rheumatoid arthritis,” Arthritis and Rheumatism, vol. 48, no. 7, pp. 1849–1852, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. G. E. O'Keefe, D. L. Hybki, and R. S. Munford, “The G→A single nucleotide polymorphism at the -308 position in the tumor necrosis factor-α promoter increases the risk for severe sepsis after trauma,” Journal of Trauma, vol. 52, no. 5, pp. 817–825, 2002. View at Google Scholar · View at Scopus
  12. A. W. Bushley, R. Ferrell, K. McDuffie et al., “Polymorphisms of interleukin (IL)-1α, IL-1β, IL-6, IL-10, and IL-18 and the risk of ovarian cancer,” Gynecologic Oncology, vol. 95, no. 3, pp. 672–679, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. I. Duarte, A. Santos, H. Sousa et al., “G-308A TNF-α polymorphism is associated with an increased risk of invasive cervical cancer,” Biochemical and Biophysical Research Communications, vol. 334, no. 2, pp. 588–592, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. X. Chen, S. Han, S. Wang et al., “Interactions of IL-12A and IL-12B polymorphisms on the risk of cervical cancer in Chinese women,” Clinical Cancer Research, vol. 15, no. 1, pp. 400–405, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Sousa, A. M. Santos, R. Catarino, D. Pinto, J. Moutinho, and P. Canedo, “IL-1RN VNTR polymorphism and genetic susceptibility to cervical cancer in Portugal,” Molecular Biology Reports, vol. 39, no. 12, pp. 10837–10842, 2012. View at Google Scholar
  16. J. W. Kim, J. W. Roh, N. H. Park, Y. S. Song, S. B. Kang, and H. P. Lee, “Interferon, alpha 17 (IFNA17) Ile184Arg polymorphism and cervical cancer risk,” Cancer Letters, vol. 189, no. 2, pp. 183–188, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. E. S. Calhoun, R. M. McGovern, C. A. Janney et al., “Host genetic polymorphism analysis in cervical cancer,” Clinical Chemistry, vol. 48, no. 8, pp. 1218–1224, 2002. View at Google Scholar · View at Scopus
  18. Q. Wang, C. Zhang, S. Walayat, H. W. Chen, and Y. Wang, “Association between cytokine gene polymorphisms and cervical cancer in a Chinese population,” European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 158, no. 2, pp. 330–333, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. L. Miteva and S. Stanilova, “The combined effect of interleukin (IL)-10 and IL-12 polymorphisms on induced cytokine production,” Human Immunology, vol. 69, no. 9, pp. 562–566, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. V. Pravica, C. Perrey, A. Stevens, J.-H. Lee, and I. V. Hutchinson, “A single nucleotide polymorphism in the first intron of the human IFN-γ gene: absolute correlation with a polymorphic CA microsatellite marker of high IFN-γ production,” Human Immunology, vol. 61, no. 9, pp. 863–866, 2000. View at Publisher · View at Google Scholar · View at Scopus
  21. J. H. Shepherd, “Staging announcement: FIGO staging of gynecologic cancers; cervical and vulva,” International Journal of Gynecological Cancer, vol. 5, pp. 319–323, 1995. View at Google Scholar
  22. C. Perrey, S. J. Turner, V. Pravica, W. M. Howell, and I. V. Hutchinson, “ARMS-PCR methodologies to determine IL-10, TNF-α, TNF-β and TGF-β1 gene polymorphisms,” Transplant Immunology, vol. 7, no. 2, pp. 127–128, 1999. View at Publisher · View at Google Scholar · View at Scopus
  23. C. Perrey, V. Pravica, P. J. Sinnott, and I. V. Hutchinson, “Genotyping for polymorphisms in interferon-γ, interleukin-10, transforming growth factor-β1 and tumour necrosis factor-α genes: a technical report,” Transplant Immunology, vol. 6, no. 3, pp. 193–197, 1998. View at Publisher · View at Google Scholar · View at Scopus
  24. T. L. Whiteside, “Immune suppression in cancer: effects on immune cells, mechanisms and future therapeutic intervention,” Seminars in Cancer Biology, vol. 16, no. 1, pp. 3–15, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. F. Liu, B. Li, Y.-G. Wei et al., “IFN-γ+874 A/T polymorphism and cancer risk: an updated analysis based on 32 case-control studies,” Cytokine, vol. 56, no. 2, pp. 200–207, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. J. Ni, Y. Ye, F. Teng, and Q. Wu, “Interleukin 10 polymorphisms and cervical cancer risk: a meta-analysis,” International Journal of Gynecological Cancer, vol. 23, no. 1, pp. 126–133, 2012. View at Publisher · View at Google Scholar
  27. Y.-G. Wei, F. Liu, B. Li et al., “Interleukin-10 gene polymorphisms and hepatocellular carcinoma susceptibility: a meta-analysis,” World Journal of Gastroenterology, vol. 17, no. 34, pp. 3941–3947, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. K. Schroder, P. J. Hertzog, T. Ravasi, and D. A. Hume, “Interferon-γ: an overview of signals, mechanisms and functions,” Journal of Leukocyte Biology, vol. 75, no. 2, pp. 163–189, 2004. View at Publisher · View at Google Scholar · View at Scopus
  29. A. Gey, P. Kumari, A. Sambandam et al., “Identification and characterisation of a group of cervical carcinoma patients with profound downregulation of intratumoral type 1 (IFNγ) and Type 2 (IL-4) cytokine mRNA expression,” European Journal of Cancer, vol. 39, no. 5, pp. 595–603, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. J. H. Bream, M. Carrington, S. O'Toole et al., “Polymorphisms of the human IFNG gene noncoding regions,” Immunogenetics, vol. 51, no. 1, pp. 50–58, 2000. View at Google Scholar · View at Scopus
  31. F. P. Schena, G. Cerullo, D. D. Torres et al., “Role of interferon-γ gene polymorphisms in susceptibility to IgA nephropathy: a family-based association study,” European Journal of Human Genetics, vol. 14, no. 4, pp. 488–496, 2006. View at Publisher · View at Google Scholar · View at Scopus
  32. T. Satoh, J. P. Pandey, Y. Okazaki et al., “Single nucleotide polymorphisms of the inflammatory cytokine genes in adults with chronic immune thrombocytopenic purpura,” British Journal of Haematology, vol. 124, no. 6, pp. 796–801, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. Z. Ben-Ari, E. Mor, O. Papo et al., “Cytokine gene polymorphisms in patients infected with hepatitis B virus,” American Journal of Gastroenterology, vol. 98, no. 1, pp. 144–150, 2003. View at Publisher · View at Google Scholar · View at Scopus
  34. M. K. K. Tamandani, R. C. Sobti, M. Shekari, M. Mukesh, and V. Suri, “Expression and polimorphism of IFN-γ gene in patients with cervical cancer,” Experimental Oncology, vol. 30, no. 3, pp. 224–229, 2008. View at Google Scholar · View at Scopus
  35. R. Gangwar, S. Pandey, and R. D. Mittal, “Association of interferon-α +874A polymorphism with the risk of developing cervical cancer in north-Indian population,” BJOG, vol. 116, no. 12, pp. 1671–1677, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. E. L. Ivansson, I. Juko-Pecirep, and U. B. Gyllensten, “Interaction of immunological genes on chromosome 2q33 and IFNG in susceptibility to cervical cancer,” Gynecologic Oncology, vol. 116, no. 3, pp. 544–548, 2010. View at Publisher · View at Google Scholar · View at Scopus
  37. V. A. Govan, H. R. O. Carrara, J. A. Sachs, M. Hoffman, G. A. Stanczuk, and A.-L. Williamson, “Ethnic differences in allelic distribution of IFN-g in South African women but no link with cervical cancer,” Journal of Carcinogenesis, vol. 2, article 3, 2003. View at Publisher · View at Google Scholar · View at Scopus
  38. A. P. M. Fernandes, M. A. G. Gonçalves, R. T. Simões, C. T. Mendes-Junior, G. Duarte, and E. A. Donadi, “A pilot case-control association study of cytokine polymorphisms in Brazilian women presenting with HPV-related cervical lesions,” European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 140, no. 2, pp. 241–244, 2008. View at Publisher · View at Google Scholar · View at Scopus
  39. Y.-Y. Mi, Q.-Q. Yu, B. Xu et al., “Interferon gamma +874 T/A polymorphism contributes to cancer susceptibility: a meta-analysis based on 17 case-control studies,” Molecular Biology Reports, vol. 38, no. 7, pp. 4461–4467, 2011. View at Publisher · View at Google Scholar · View at Scopus
  40. C. M. Hawrylowicz and A. O'Garra, “Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma,” Nature Reviews Immunology, vol. 5, no. 4, pp. 271–283, 2005. View at Publisher · View at Google Scholar · View at Scopus
  41. E. Alamartine, P. Berthoux, C. Mariat, F. Cambazard, and F. Berthoux, “Interleukin-10 promoter polymorphisms and susceptibility to skin squamous cell carcinoma after renal transplantation,” Journal of Investigative Dermatology, vol. 120, no. 1, pp. 99–103, 2003. View at Publisher · View at Google Scholar · View at Scopus
  42. G. A. Stanczuk, E. N. Sibanda, C. Perrey et al., “Cancer of the uterine cervix may be significantly associated with a gene polymorphism coding for increased IL-10 production,” International Journal of Cancer, vol. 94, no. 6, pp. 792–794, 2001. View at Publisher · View at Google Scholar · View at Scopus
  43. M. Zoodsma, I. M. Nolte, M. Schipper et al., “Interleukin-10 and Fas polymorphisms and susceptibility for (pre)neoplastic cervical disease,” International Journal of Gynecological Cancer, vol. 15, no. 6, pp. 282–290, 2005. View at Publisher · View at Google Scholar · View at Scopus
  44. K. Szöke, A. Szalmás, G. Szládek et al., “IL-10 promoter nt -1082A/G polymorphism and human papillomavirus infection in cytologic abnormalities of the uterine cervix,” Journal of Interferon and Cytokine Research, vol. 24, no. 4, pp. 245–251, 2004. View at Publisher · View at Google Scholar · View at Scopus
  45. G. Barbisan, L. O. Pérez, A. Contreras, and C. D. Golijow, “TNF-α and IL-10 promoter polymorphisms, HPV infection, and cervical cancer risk,” Tumor Biology, vol. 33, no. 5, pp. 1549–1556, 2012. View at Publisher · View at Google Scholar