Table of Contents
International Scholarly Research Notices
Volume 2014 (2014), Article ID 738493, 9 pages
http://dx.doi.org/10.1155/2014/738493
Research Article

Investigation of Pharmacological Activity of Caralluma penicillata: Anti-Inflammatory Properties and Gastritis Protection against Indomethacin in Adult Guinea Pigs

1Department of Pharmacology and Therapeutic, Faculty of Medicine and Health Sciences, Sana’a University, Sana’a, Yemen
2Tihama Foundation for Drug Studies and Research, Hodeidah, Yemen
3Department of Pharmacy Practice, Faculty of Clinical Pharmacy, Hodeidah University, P.O. Box 3114, Hodeidah, Yemen

Received 17 July 2014; Accepted 15 October 2014; Published 4 December 2014

Academic Editor: Carmela Saturnino

Copyright © 2014 Nabil Albaser et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Caralluma is a plant that possessing a great therapeutic potential in folk medicine in Yemen, namely, Caralluma penicillata (C. penicillata) as antiulcer. The study aims to evaluate the anti-inflammatory properties and gastritis protection activity of C. penicillata against indomethacin in adult guinea pigs. The study was divided into four parts: firstly, the optimum dose of extract as anti-inflammatory effect was determined. Secondly, the acute anti-inflammatory effect of extract were estimated. Thirdly, the repeated doses of extract against chronic inflammation was estimated. The anti-inflammatory activity of extract was compared with indomethacin as a prototype of drug against inflammation. Fourthly, the gastritis protection properties of extract with/without indomethacin were performed. The results showed that a 400 mg/kg of 10% ethanol extract produced the maximum of anti-inflammatory effect. Also, the single dose of extract was equipotent for indomethacin (10 mg/kg), but shorter in duration with regard to acute anti-inflammatory effect. In addition, the repeated doses of extract against chronic inflammation were less potent than indomethacin with regard to ulcerogenic effect. On the other hand, extract-indomethacin combination reduced the gastritis effect of indomethacin based on ulcer index and histological study.