Investigation of Pharmacological Activity of Caralluma penicillata: Anti-Inflammatory Properties and Gastritis Protection against Indomethacin in Adult Guinea Pigs
Table 2
Effect of single dose intragastric administration of 10% ethanol extract of C. penicillata (400 mg/kg) versus indomethacin (10 mg/kg) on average (M ± SE) volume (cubic centimeter) of fresh egg albumin (0.5 mL/kg) induced paw oedema as a model of chronic inflammation ( = 6).
Groups
Original paw volume
Average volume of paw (M ± SE) paw volume (cubic centimeter)
30 min
60 min
90 min
120 min
150 min
180 min
Nontreated control Difference of paw volume (cc)
3.15 ± 0.10
3.82 ± 0.13*
3.95 ± 0.13*
4.35 ± 0.14*
4.0 ± 0.16*
3.9 ± 0.15*
3.57 ± 0.14*
0.7 ± 0.04
0.80 ± 0.04
1.2 ± 0.03
0.85 ± 0.05
0.75 ± 0.04
0.42 ± 0.03
Indomethacin (10 mg/kg) Difference of paw volume (cc)
3.18 ± 0.11
3.68 ± 0.12*
3.78 ± 0.11*
3.65 ± 0.08*
3.48 ± 0.04*
3.35 ± 0.10
3.30 ± 0.1+
0.50 ± 0.05+
0.60 ± 0.03+
0.47 ± 0.03+
0.30 ± 0.03+
0.17 ± 0.02+
0.12 ± 0.01+
C. penicillata (400 mg/kg) Difference of paw volume (cc)
3.15 ± 0.10
3.57 ± 0.11*
3.67 ± 0.09*
3.65 ± 0.10*
3.57 ± 0.11*
3.47 ± 0.11*
3.42 ± 0.09*
0.42 ± 0.03+
0.52 ± 0.04+
0.50 ± 0.05
0.42 ± 0.0
0.32 ± 0.0
0.27 ± 0.0
Significantly compared with original paw volume at .
+Significantly compared with nontreated control group at . Significantly compared with indomethacin group at .
