Table of Contents
ISRN Pharmacology
Volume 2014, Article ID 741478, 4 pages
http://dx.doi.org/10.1155/2014/741478
Research Article

The Useful Medicinal Properties of the Root-Bark Extract of Alstonia boonei (Apocynaceae) May Be Connected to Antioxidant Activity

1Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, PMB 5025, Awka, Anambra State, Nigeria
2Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, PMB 5025, Awka, Anambra State, Nigeria

Received 8 October 2013; Accepted 4 December 2013; Published 27 January 2014

Academic Editors: R. Villalobos-Molina and T. B. Vree

Copyright © 2014 Miracle Oluebubechukwu Obiagwu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Folkloric use of root-bark extract of Alstonia boonei in the treatment and management of many disease conditions may be associated with free radical scavenging as part of its mechanisms of action. We therefore evaluated the ability of different solvent fractions of the methanol extract, crude precipitate from the extract, and isolated compound from the crude precipitate for scavenging 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical. Phytochemical analysis revealed the presence of useful phytocompounds. Ethyl acetate fraction showed better antioxidant activity with IC50 of 54.25 μg/mL while acetone and methanol fractions have 121.79 and 141.67 μg/mL, respectively. The crude precipitate and isolated compound showed IC50 values of 364.39 and 354.94 μg/mL, respectively. The crude precipitate, fractions, and compound 1 showed antioxidant activity against DPPH radical although lower than that of ascorbic acid.