Table of Contents
ISRN Hematology
Volume 2014 (2014), Article ID 745245, 6 pages
http://dx.doi.org/10.1155/2014/745245
Research Article

Prevalence of Deletional Alpha Thalassemia and Sickle Gene in a Tribal Dominated Malaria Endemic Area of Eastern India

1Sickle Cell Clinic & Molecular Biology Laboratory, Veer Surendra Sai Medical College, Burla, Sambalpur, Odisha 768017, India
2Department Medicine, Sickle Cell Clinic & Molecular Biology Laboratory, Veer Surendra Sai Medical College, Burla, Sambalpur, Odisha 768017, India
3Department of Medicine, Sickle Cell Clinic & Molecular Biology Laboratory, Veer Surendra Sai Medical College, Qr. 3R/27, Doctors Colony, Burla, Sambalpur, Odisha 768017, India

Received 15 January 2014; Accepted 18 February 2014; Published 11 March 2014

Academic Editors: S. E. Cox and J. L. Vives-Corrons

Copyright © 2014 Prasanta Purohit et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

We undertook a study entitled “Influence of heterozygous and homozygous alpha thalassemia on the severity of P. falciparum malaria in India.” sponsored by Department of Science and Technology (DST), Government of India, New Delhi. This was a case control study undertaken at V. S. S. Medical College, Burla, Odisha, from 2010 to 2013. All the confirmed cases of Plasmodium falciparum infection with severe malaria admitted in Department of Medicine, V.S.S. Medical College, Burla were included (N=279). Cases were categorized in to three groups (Normal alpha globin genotype, αα/αα; heterozygous alpha thalassemia, -α/αα; and homozygous alpha thalassemia, -α/-α). These cases in the three groups were compared with age, sex and ethnicity matched healthy controls (N=271) (Table-1). The prevalence of both heterozygous and homozygous alpha thalassemia was significantly lower (p<0.05) in severe malaria cases (38.7%) than in healthy controls (48.0%), which indicated that the deletional alpha thalassemia has a protective effect against severe P falciparum malaria. The clinical profile of all patients showed that the patients with alpha thalassemia (both heterozygous and homozygous) had a significant protective effect from cerebral malaria, multi organ dysfunction, Jaundice, Acute renal failure, and death from patients with normal alpha globin genes (p<0.05 by Fisher’s exact test) (Table-2).

  1. Supplementary Material