International Scholarly Research Notices / 2014 / Article / Tab 1

Clinical Study

Efficacy and Clinical Determinants of Antipsychotic Polypharmacy in Psychotic Patients Experiencing an Acute Relapse and Admitted to Hospital Stay: Results from a Cross-Sectional and a Subsequent Longitudinal Pilot Study

Table 1

Patients’ demographics and clinical variables in the cross-sectional study.

AP + APAP Effect sizedf

Age (years)46.3 ± 11.551.2 ± 14.1*0.048 : 1.99143
Gender m/f18/2354/500.761
Age at onset (years)21.6 ± 7.533.5 ± 14.5*0.0001 : 4.14114
Duration of disease (years)22.8 ± 8.2*18.1 ± 11.60.046 : 2.02117
Diagnosis (%)
(i) Schizophrenia25 (63.4%)*23 (22.3%)0.00003 : 23.443
(ii) Schizoaffective6 (5.8%)2 (5%)
(iii) Bipolar disorder type I7 (18%)29 (29%)
(iv) Bipolar disorder NOS5 (12.8%)45 (43.7%)*
Comorbid diagnosis ( ):
(i) Mental retardation5 (31.2%)*3 (4.3%)0.0013 : 13.183
(ii) Cognitive impairment0 (0%)13 (18.8%)
(iii) Alcoholism10 (62.5%)35 (50.7%)
(iv) Personality disorder1 (6.2%)18 (26.1%)
Psychotropic drugs (%)
(i) First generation antipsychotics46 (35.1%)*4 (1.8%)<0.00001 : 83.635
(ii) Second generation antipsychotics43 (32.8%)81 (37.8%)
(iii) Mood stabilizers26 (19.8%)85 (39.7%)*
(iv) Antidepressants13 (9.9%)16 (7.5%)
(v) Benzodiazepines3 (2.3%)28 (13.1%)*
(vi) Anticholinergics3 (2.3%)2 (0.9%)
Antipsychotic doses (in mg/day chlorpromazine equivalents)954.46 ± 405.71*328.72 ± 180.12<0.00001 : 11.96143

In this table we summarized data on (i) demographics in patients receiving antipsychotics polytherapy (AP + AP) compared to patients receiving one antipsychotic only (AP); (ii) rates and distribution of psychiatric and organic comorbid diagnoses in AP + AP versus AP patients; (iii) rates and distribution of antipsychotic and non-antipsychotic psychotropic agents in AP + AP versus AP patients; (iv) antipsychotic doses (in mean mg/day chlorpromazine equivalents) in AP + AP versus AP patients. Demographic and pharmacological variables were compared by Student’s test. Diagnosis and antipsychotic distribution were compared by chi-square test. Significant values have been marked in bold and with an asterisk and given with effect size ( , ). The bold italic items refer to the category where significant differences between groups have been found. df: degrees of freedom.

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