Table of Contents
International Scholarly Research Notices
Volume 2014, Article ID 765895, 5 pages
http://dx.doi.org/10.1155/2014/765895
Research Article

Malnutrition Markers and Serum Ghrelin Levels in Hemodialysis Patients

1Pregnancy Health Research Center, Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9854, Iran
2Health Promotion Research Center, Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9854, Iran
3Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9854, Iran

Received 19 July 2014; Revised 28 September 2014; Accepted 2 October 2014; Published 30 October 2014

Academic Editor: Chih-Yen Chen

Copyright © 2014 Farzaneh Montazerifar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. The aim of study was to investigate the changes levels of serum ghrelin in HD patients and its relationship to some malnutrition markers compared with healthy controls. Methods. Forty-five patients on hemodialysis and forty healthy controls were studied. Biochemical parameters and serum ghrelin levels were measured. Both daily dietary intakes and body mass index (BMI) assessments were performed for evaluation of nutritional status. Results. Ghrelin concentrations were significantly reduced in patients undergoing hemodialysis when compared to healthy controls ( (1.1–18.5) pg/mL versus (2.4–18.3) pg/mL; ). BMI and serum albumin in HD patients were markedly reduced compared to controls. The patients with an insufficient intake of energy and protein demonstrated slightly lower levels of serum ghrelin. A negative correlation between serum ghrelin concentration with age (, ), BUN (, ), and serum creatinine (, ) was observed in HD patients. Conclusions. The findings suggest that decreased ghrelin levels in HD patients might be associated with anorexia. Further studies are needed to determine changes in serum ghrelin levels during dialysis and to clarify whether the decrease in ghrelin levels contributes to the malnutrition that is common in these patients.