Table of Contents
ISRN Urology
Volume 2014, Article ID 794563, 9 pages
http://dx.doi.org/10.1155/2014/794563
Review Article

Sarcomatoid Variant of Urothelial Carcinoma (Carcinosarcoma, Spindle Cell Carcinoma): A Review of the Literature

1North Manchester General Hospital, Department of Urology, Delaunays Road, Crumpsall, Manchester, UK
2Royal Oldham Hospital, Department of Histopathology, Rochdale Road, Oldham, UK

Received 23 September 2013; Accepted 9 November 2013; Published 22 January 2014

Academic Editors: J. H. Ku and V. Serretta

Copyright © 2014 Anthony Kodzo-Grey Venyo and Sami Titi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. N. . Eble, G. Sauter, J. I. Epstein, and I. A. E. Sesterhenn, World Health Organization classification of tumours: pathology and genetics of tumours of the urinary system and male genital organs, IARC Press, Lyon, France, 2004.
  2. A. Lopez-Beltran, A. Pacelli, H. J. Rothenberg et al., “Carcinosarcoma and sarcomatoid carcinoma of the bladder: clinicopathological study of 41 cases,” Journal of Urology, vol. 159, no. 5, pp. 1497–1503, 1998. View at Google Scholar · View at Scopus
  3. P. C. Black, G. A. Brown, and C. P. N. Dinney, “The impact of variant histology on the outcome of bladder cancer treated with curative intent,” Urologic Oncology, vol. 27, no. 1, pp. 3–7, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. J. L. Wright, P. C. Black, G. A. Brown et al., “Differences in survival among patients with sarcomatoid carcinoma, carcinosarcoma and urothelial carcinoma of the bladder,” Journal of Urology, vol. 178, no. 6, pp. 2302–2307, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Lopez-Beltran, A. L. Escudero, A. O. Cavazzana, L. G. Spagnoli, and L. Vicioso-Recio, “Sarcomatoid transitional cell carcinoma of the renal pelvis: a report of five cases with clinical, pathological, immunohistochemical and DNA ploidy analysis,” Pathology Research and Practice, vol. 192, no. 12, pp. 1218–1224, 1996. View at Google Scholar · View at Scopus
  6. E. C. Jones and R. H. Young, “Myxoid and sclerosing sarcomatoid transitional cell carcinoma of the urinary bladder: a clinicopathologic and immunohistochemical study of 25 cases,” Modern Pathology, vol. 10, no. 9, pp. 908–916, 1997. View at Google Scholar · View at Scopus
  7. T. Tsuzuki, C. Magi-Galluzzi, and J. I. Epstein, “ALK-1 expression in inflammatory myofibroblastic tumor of the urinary bladder,” American Journal of Surgical Pathology, vol. 28, no. 12, pp. 1609–1614, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. L. Cheng, S. R. Foster, G. T. MacLennan, A. Lopez-Beltran, S. Zhang, and R. Montironi, “Inflammatory myofibroblastic tumors of the genitourinary tract-single entity or continuum?” Journal of Urology, vol. 180, no. 4, pp. 1235–1240, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Lott, A. Lopez-Beltran, G. T. MacLennan, R. Montironi, and L. Cheng, “Soft tissue tumors of the urinary bladder, part I: myofibroblastic proliferations, benign neoplasms, and tumors of uncertain malignant potential,” Human Pathology, vol. 38, no. 6, pp. 807–823, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Lopez-Beltran, “The diverse morphological faces of carcinoma of urinary bladder,” in Proceedings of the 100th Annual Meeting (USCAP '11), San Antonio, Tex, USA, February 2011, http://www.docstoc.com/docs/117703875/The-Diverse-Morphological-Faces-of-Carcinoma-of-Urinary-Bladder, http://www.isuporg.org/files/companionMeetings2003-2011.pdf.
  11. M.-T. Sung, M. Wang, G. T. MacLennan et al., “Histogenesis of sarcomatoid urothelial carcinoma of the urinary bladder: evidence for a common clonal origin with divergent differentiation,” Journal of Pathology, vol. 211, no. 4, pp. 420–430, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. A. B. Armstrong, M. Wang, J. N. Eble et al., “TP53 mutational analysis supports monoclonal origin of biphasic sarcomatoid urothelial carcinoma (carcinosarcoma) of the urinary bladder,” Modern Pathology, vol. 22, no. 1, pp. 113–118, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. P. C. Black, G. A. Brown, and C. P. N. Dinney, “Clinical and therapeutic significance of aberrant differentiation patterns in bladder cancer,” Expert Review of Anticancer Therapy, vol. 7, no. 7, pp. 1015–1026, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. V. Chalasani, J. L. Chin, and J. I. Izawa, “Histologic variants of urothelial bladder cancer and nonurothelial histology in bladder cancer,” Journal of the Canadian Urological Association, vol. 3, no. 6, supplement 4, pp. S193–S198, 2009. View at Google Scholar · View at Scopus
  15. M. B. Amin, “Histological variants of urothelial carcinoma: diagnostic, therapeutic and prognostic implications,” Modern Pathology, vol. 22, supplement 2, pp. S96–S118, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. M. F. Acikalin, S. Kabukcuoglu, and C. Can, “Sarcomatoid carcinoma of the renal pelvis with giant cell tumor-like features: case report with immunohistochemical findings,” International Journal of Urology, vol. 12, no. 2, pp. 199–203, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. R. H. Young, M. R. Wick, and S. E. Mills, “Sarcomatoid carcinoma of the urinary bladder. A clinicopathologic analysis of 12 cases and review of the literature,” American Journal of Clinical Pathology, vol. 90, no. 6, pp. 653–661, 1988. View at Google Scholar · View at Scopus
  18. R. Torenbeek, C. E. M. Blomjous, P. C. De Bruin, D. W. W. Newling, and C. J. L. M. Meijer, “Sarcomatoid carcinoma of the urinary bladder: clinicopathologic analysis of 18 cases with immunohistochemical and electron microscopic findings,” American Journal of Surgical Pathology, vol. 18, no. 3, pp. 241–249, 1994. View at Google Scholar · View at Scopus
  19. H. Ikegami, H. Iwasaki, Y. Ohjimi, T. Takeuchi, A. Ariyoshi, and M. Kikuchi, “Sarcomatoid carcinoma of the urinary bladder: a clinicopathologic and immunohistochemical analysis of 14 patients,” Human Pathology, vol. 31, no. 3, pp. 332–340, 2000. View at Google Scholar · View at Scopus
  20. V. E. Reuter, “Sarcomatoid lesions of the urogenital tract,” Seminars in Diagnostic Pathology, vol. 10, no. 2, pp. 188–201, 1993. View at Google Scholar · View at Scopus
  21. R. H. Young and M. R. Wick, “Transitional cell carcinoma of the urinary bladder with pseudosarcomatous stroma,” American Journal of Clinical Pathology, vol. 90, no. 2, pp. 216–219, 1988. View at Google Scholar · View at Scopus
  22. M. R. Wick and P. E. Swanson, “Carcinosarcomas: current perspectives and an historical review of nosological concepts,” Seminars in Diagnostic Pathology, vol. 10, no. 2, pp. 118–127, 1993. View at Google Scholar · View at Scopus
  23. S. K. Shah, P. D. Lui, D. D. Baldwin, and H. C. Ruckle, “Urothelial carcinoma after external beam radiation therapy for prostate Cancer,” Journal of Urology, vol. 175, no. 6, pp. 2063–2066, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. L. R. Harik, C. Merino, J.-M. Coindre, M. B. Amin, F. Pedeutour, and S. W. Weiss, “Pseudosarcomatous myofibroblastic proliferations of the bladder: a clinicopathologic study of 42 cases,” American Journal of Surgical Pathology, vol. 30, no. 7, pp. 787–794, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. D. E. Westfall, A. L. Folpe, G. P. Paner et al., “Utility of a comprehensive immunohistochemical panel in the differential diagnosis of spindle cell lesions of the urinary bladder,” American Journal of Surgical Pathology, vol. 33, no. 1, pp. 99–105, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. J. K. McKenney and M. B. Amin, “The role of immunohistochemistry in the diagnosis of urinary bladder neoplasms,” Seminars in Diagnostic Pathology, vol. 22, no. 1, pp. 69–87, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. Q. J. Zhai, J. Black, A. G. Ayala, and J. Y. Ro, “Histologic variants of infiltrating urothelial carcinoma,” Archives of Pathology and Laboratory Medicine, vol. 131, no. 8, pp. 1244–1256, 2007. View at Google Scholar · View at Scopus
  28. B. Arun, N. Bylu, S. Varghese, M. K. Manu, G. S. Kumar, and K. Syam, “Sarcomatoid variant of urothelial carcinoma: a case report,” Indian Journal of Urology. In press.
  29. N. A. Sarkissian and J. F. Lara, “High grade transitional cell carcinoma of the renal pelvis with divergent differentiation mimicking a renal abscess,” The Open Pathology Journal, vol. 2, pp. 115–1119, 2008. View at Google Scholar
  30. R. A. Leder and N. R. Dunnick, “Transitional cell carcinoma of the pelvicalices and ureter,” American Journal of Roentgenology, vol. 155, no. 4, pp. 713–722, 1990. View at Google Scholar · View at Scopus
  31. S. M. Cohen and S. L. Johansson, “Epidemiology and etiology of bladder cancer,” Urologic Clinics of North America, vol. 19, no. 3, pp. 421–428, 1992. View at Google Scholar · View at Scopus
  32. F. Piscioli, A. Bondi, P. Scappini, and L. Luciani, “‘True’ sarcomatoid carcinoma of the renal pelvis. First case report with immunocytochemical study (with 1 color plate),” European Urology, vol. 10, no. 5, pp. 350–355, 1984. View at Google Scholar · View at Scopus
  33. D. D. Thiel, T. C. Igel, and K. J. Wu, “Sarcomatoid carcinoma of transitional cell origin confined to renal pelvis,” Urology, vol. 67, no. 3, pp. 622.e9–622.e11, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. M. R. Wick, T. L. Perrone, and B. A. Burke, “Sarcomatoid transitional cell carcinomas of the renal pelvis. An ultrastructural and immunohistochemical study,” Archives of Pathology and Laboratory Medicine, vol. 109, no. 1, pp. 55–58, 1985. View at Google Scholar · View at Scopus
  35. Y. Sekido, F. Satoh, Y. Usui, and Y. Tsutsumi, “Sarcomatoid carcinoma of the renal pelvis: a case report,” Pathology International, vol. 50, no. 7, pp. 562–567, 2000. View at Publisher · View at Google Scholar · View at Scopus
  36. B. Delahunt, “Sarcomatoid renal carcinoma: the final common dedifferentiation pathway of renal epithelial malignancies,” Pathology, vol. 31, no. 3, pp. 185–190, 1999. View at Publisher · View at Google Scholar · View at Scopus
  37. V. Nagy, H. Schneider, L. Valanský, and L. Sokol, “Sarcomatous dedifferentiated renal cell carcinoma mimicking a severe purulent kidney infection,” Urologia Internationalis, vol. 76, no. 1, pp. 77–81, 2006. View at Publisher · View at Google Scholar · View at Scopus
  38. D. Perez-Montiel, P. E. Wakely Jr., O. Hes, M. Michal, and S. Suster, “High-grade urothelial carcinoma of the renal pelvis: clinicopathologic study of 108 cases with emphasis on unusual morphologic variants,” Modern Pathology, vol. 19, no. 4, pp. 494–503, 2006. View at Publisher · View at Google Scholar · View at Scopus
  39. J. B. Wallach, B. Wang, and N. Sanfilippo, “High-grade hyperinvasive sarcomatoid urothelial bladder carcinoma demonstrating complete response to bladder-preserving chemoradiation,” Current Oncology, vol. 16, no. 3, pp. 55–57, 2009. View at Google Scholar · View at Scopus
  40. R. Sauer, S. Birkenhake, R. Kühn, C. Wittekind, K. M. Schrott, and P. Martus, “Efficacy of radiochemotherapy with platin derivatives compared to radiotherapy alone in organ-sparing treatment of bladder cancer,” International Journal of Radiation Oncology Biology Physics, vol. 40, no. 1, pp. 121–127, 1998. View at Publisher · View at Google Scholar · View at Scopus
  41. J. E. Castelao, J.-M. Yuan, P. L. Skipper et al., “Gender- and smoking- related bladder cancer risk,” Journal of the National Cancer Institute, vol. 93, no. 7, pp. 538–545, 2001. View at Google Scholar · View at Scopus
  42. M. Froehner, H. J. Gaertner, A. Manseck, and M. P. Wirth, “Durable complete remission of metastatic sarcomatoid carcinoma of the bladder with cisplatin and gemcitabine in an 80-year-old man,” Urology, vol. 58, no. 5, p. 799, 2001. View at Google Scholar · View at Scopus
  43. S. Hoshi, M. Sasaki, A. Muto et al., “Case of carcinosarcoma of urinary bladder obtained a pathologically complete response by neoadjuvant chemoradiotherapy,” International Journal of Urology, vol. 14, no. 1, pp. 79–81, 2007. View at Publisher · View at Google Scholar · View at Scopus
  44. M. Nomikos, P. Philippou, C. Glava, and D. Delakas, “Urothelial carcinoma of the sarcomatoid variant in a young patient with spina bifida: a case report and review of the literature,” Cases Journal, vol. 2, no. 12, article 9381, 2009. View at Publisher · View at Google Scholar · View at Scopus
  45. D. Bostwick and L. Cheng, Urologic Surgical Pathology, Mosby Elsevier, Edinburgh, UK, 2nd edition, 2008.
  46. J. Wang, C. Gilespie, R. Kunadharaju, G. A. Taimon, and C. Enke, “Sarcomatoid urothelial carcinoma: a single center experience,” World Journal of Oncology, vol. 2, no. 4, pp. 175–1180, 2011. View at Google Scholar
  47. N. Arita, M. Ishida, K. Yoshida et al., “Sarcomatoid variant of urothelial carcinoma: cytological analysis of three cases,” Oncology Letters, vol. 5, no. 1, pp. 49–452, 2013. View at Google Scholar