Table of Contents
International Scholarly Research Notices
Volume 2014 (2014), Article ID 820921, 5 pages
http://dx.doi.org/10.1155/2014/820921
Research Article

Characteristics of Primary Cutaneous T-Cell Lymphoma in Iran: A 10-Year Retrospective Study

1Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2Students’ Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
3Students’ Research Committee, Semnan University of Medical Sciences, Semnan, Iran
4Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Received 8 September 2014; Revised 29 November 2014; Accepted 10 December 2014; Published 24 December 2014

Academic Editor: Mauro Alaibac

Copyright © 2014 Farahnaz Fatemi Naeini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Primary cutaneous T-cell lymphomas (CTCLs) are a group of extranodal non-Hodgkin lymphomas that may be present in the skin without any evidence of extracutaneous disease. The aim of this study was to evaluate the epidemiological characteristics of primary CTCL in Isfahan, Iran. Method. A total of 95 patients who were diagnosed as having primary CTCL were recruited during a 10-year period (2003–2013) and were classified according to the new WHO-EORTC criteria. Results. The patient group consisted of 43 (44.8%) males and 53 (55.2%) females, which indicated a female predominance (M : F ratio 1 : 1.2). The mean age at the time of diagnosis was 41.78 ± 16.88 years (range: 7–84 years). Prior to diagnosis, the lesions had persisted for a mean of 8.34 ± 4.38 years (range: 0–55 years). The age at peak diagnosis was 20–40 years (43%). The most frequent subtypes were mycosis fungoides (MF) (88.5%). Four patients died from CTCL-related complications. Conclusions. The distinguishing epidemiologic characteristics of primary CTCL, particularly those MF, in Iran, are the absence of a male predominance and lower age at diagnosis. This is likely because of the characteristic ethnic group diversity and increased susceptibility among younger population.