Factor VIII-Related Antigen Detects Phenotypic Change of Sinusoidal to Vascular Endothelium in Hepatic Fibrosis of Elderly Cadavers
Figure 2
Immunostaining of vascular endothelium of central veins for FVIIIRAg. (a) Fibrotic central vein. The black lines indicate the wall of the vein (measured >10 μm), which is thickened by fibrous tissue—slightly gray after hematoxylin counterstaining. FVIIIRAg immune deposits (brown color) are clearly visible in the endothelial cells—particularly in the cytoplasmic processes. The matrix of the fibrous tissue is negative for FVIIIRAg. (b) Nonfibrotic central vein. The wall is thin, but the endothelium is stained positively for FVIIIRAg.
