Synthetic Melatoninergic Ligands: Achievements and Prospects

Table 1

Synthetic ligands at melatonin receptors.

Number	Compound*	Type of ligand	Reference
Melatonin derivatives
1		Agonist; MT1 and MT2	[65]
2		Agonist MT1,; antagonist MT2	[66]
3		Agonist MT3	[67]
Tri- and tetracyclic compounds
4		Antagonist MT2	[68]
5		Agonist MT2	[68]
6		Agonist; MT1 and MT2	[65]
7		Agonist; MT1 and MT2	[30]
Naphthalene and tetralin analogues
8		Agonist; MT1 and MT2	[69]
9		Antagonist MT2	[70]
“Dimeric ligands”
10		Agonist MT1	[70]
11		Antagonist MT1	[71]
Thiazolidine analogues
12		Agonist RZR/ROR	[72]

∗For ligands with low selectivity to the MT₁ and MT₂ and also for the MT₃ and RZR/ROR ligands, the values of the dissociation constants for receptor complex are shown as 𝐾¹_𝑖, 𝐾²_𝑖, 𝐾³_𝑖, 𝐾^𝑅_𝑖, respectively. For ligands of high selectivity, the ratios of the dissociation constants are given, 𝐾¹_𝑖/𝐾²_𝑖 or 𝐾²_𝑖/𝐾¹_𝑖.